| Whole-body protein turnover in metabolically stressed patients and patients with cancer as measured with [15N] glycine. | |
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MedLine Citation:
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PMID: 6626186 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The whole-body protein synthesis rate (PSR) was measured in 5 control patients (group I) and 38 patients in various clinical states (group II). A single pulse of [15N]glycine was given and the PSR calculated from the 15N enrichment in the urinary ammonia excreted over the next 10 hr. The patients' results fell into three separate groups: group IIa patients were nonstressed and had uneventful recoveries (3.1 +/- 0.6 g prot./kg/day), their PSRs were the same as the control group I, (3.1 +/- 1.0 g prot./kg/day); group IIb patients were stressed, had higher PSRs (6.3 +/- 0.9 g prot./kg/day), one of whom died, and the rest had more complications than group IIa; group IIc patients had very high PSRs (15.4 +/- 6.1 g prot./kg/day), all of whom were seriously ill, and 8 out 12 died; Data are +/- 1 SD. The PSR correlated with the serum glutamate oxaloacetate transferase (SGOT, P less than 0.01). We concluded: (i) [15N]glycine cannot be used to measure the PSR in patients with evidence of liver disease; the results are best interpreted in terms of glycine metabolism; (ii) the "apparent" PSR correlated with clinical status; and (iii) an elevated PSR in a patient with a malignancy is not necessarily due to protein metabolism by the tumor. |
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Authors:
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T P Stein; S D Ang; M D Schluter; M J Leskiw; M Nusbaum |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochemical medicine Volume: 30 ISSN: 0006-2944 ISO Abbreviation: Biochem Med Publication Date: 1983 Aug |
Date Detail:
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Created Date: 1983-11-23 Completed Date: 1983-11-23 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0151424 Medline TA: Biochem Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 59-77 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Female Glycine / metabolism* Humans Liver / metabolism Liver Function Tests Male Middle Aged Neoplasms / metabolism* Nitrogen / urine Protein Biosynthesis* Stress, Physiological / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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16658//PHS HHS |
| Chemical | |
Reg. No./Substance:
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56-40-6/Glycine; 7727-37-9/Nitrogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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