Document Detail


Whole body hyperthermia: a phase-I trial of a potential adjuvant to chemotherapy.
MedLine Citation:
PMID:  426399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fourteen patients with a variety of neoplasms not responsive to standard forms of therapy underwent whole body hyperthermia for a maximum 4 h at 41.8 degrees C. This was a phase-I cancer trial designed to develop whole body hyperthermia as an adjuvant to systemic chemotherapy. Intravenous analgesia was used to sedate patients, obviating the need for general endotracheal anesthesia. Hyperthermia was induced by means of a high-flow water perfusion suit. Cardiovascular performance was evaluated using a flow-directed pulmonary artery catheter. Patients developed a twofold mean increase in cardiac index without evidence of cardiac damage by ECG or creatine phosphokinase (CPK) isoenzymes. An acute fall in serum magnesium and phosphate and an acute rise in arterial pH, serum CPK values, and granulocyte count occurred in all patients. There were no clotting abnormalities. Toxicity included fatigue, diarrhea, nausea, and transient elevations in liver enzymes. Four patients were febrile for 36 h after initial defervescence. Peripheral neuropathy developed in four. These results show that with carefully monitored conditions whole body hyperthermia is feasible.
Authors:
J M Bull; D Lees; W Schuette; J Whang-Peng; R Smith; G Bynum; E R Atkinson; J S Gottdiener; H R Gralnick; T H Shawker; V T DeVita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of internal medicine     Volume:  90     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-05-24     Completed Date:  1979-05-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  317-23     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Cardiovascular System / physiopathology
Enzymes / analysis
Female
Hot Temperature / adverse effects,  therapeutic use*
Humans
Leukocyte Count
Male
Middle Aged
Neoplasms / drug therapy*,  therapy*
Chemical
Reg. No./Substance:
0/Enzymes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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