| Whole-body cooling after perinatal asphyxia: a pilot study in term neonates. | |
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MedLine Citation:
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PMID: 12553298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to test the practicability and safety of whole-body cooling in term neonates with moderate-to-severe hypoxic-ischaemic encephalopathy (HIE) and to report outcomes, a prospective pilot study was carried out in 25 term infants (median postmenstrual age 38 weeks, range 36 to 41 weeks; 20 males, five females). Whole-body cooling, to a target core temperature of 33 to 34 degrees C, started within 6 hours of birth and was maintained for 72 hours. Of the 25 newborn infants (19 Sarnat II and six Sarnat III, 18 outborn), 18 survived, including 13 (72%) with normal cerebral signal by MRI. Temperature instability occurred during cooling in 15 infants, but neither severe haemodynamic instability nor renal failure was seen. Thrombocytopenia developed in 12 infants, including seven with biological disseminated intravascular coagulation. One patient had hypoxaemia with right-to-left shunting through the ductus arteriosus, and seven had limited meningeal or subdural bleeding. Whole-body cooling is feasible in term neonates, with no life-threatening adverse events. Improvements are needed to obtain stable hypothermia for 72 hours. |
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Authors:
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Thierry Debillon; Patrick Daoud; Philippe Durand; Sylvain Cantagrel; Philippe Jouvet; Carole Saizou; Véronique Zupan |
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Publication Detail:
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Type: Clinical Trial; Clinical Trial, Phase II; Journal Article; Multicenter Study |
Journal Detail:
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Title: Developmental medicine and child neurology Volume: 45 ISSN: 0012-1622 ISO Abbreviation: Dev Med Child Neurol Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2003-01-28 Completed Date: 2003-02-07 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0006761 Medline TA: Dev Med Child Neurol Country: England |
Other Details:
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Languages: eng Pagination: 17-23 Citation Subset: IM |
Affiliation:
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Neonatal Intensive Care Unit, Hôpital Mère-Enfant, Centre Hospitalier Universitaire de Nantes, 44 093 Nantes 01, France. thierry.debillon@chu-nantes.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Asphyxia Neonatorum
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complications,
diagnosis,
mortality,
therapy* Body Temperature Disseminated Intravascular Coagulation / complications Feasibility Studies Female France / epidemiology Hematoma, Subdural / complications Humans Hypothermia, Induced / adverse effects, methods* Hypoxia-Ischemia, Brain / complications, diagnosis, mortality, therapy* Infant, Newborn Male Pilot Projects Prospective Studies Safety Severity of Illness Index Subarachnoid Hemorrhage / complications Survival Analysis Thrombocytopenia / complications Time Factors Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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