Document Detail

Whole body bone mineral content is similar at discharge from the hospital in premature infants receiving fortified breast milk or preterm formula.
MedLine Citation:
PMID:  16056105     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Prematurely born infants, especially those with very low birth weight (<1500 g) are at risk for metabolic bone disease. OBJECTIVES: The influence of the type of oral feeding regimen and of other potential determinants of whole bone mineral content in prematurely born infants, when they approached full gestation, were evaluated. Previous studies have mainly examined effects at the level of regional bone. METHODS: 34 infants (21 males and 13 females), all born between 25.4 and 33.7 weeks of gestation, were studied before discharge. Whole body bone mineral content measurements were made just before hospital discharge using a commercial densitometer (Hologic QDR 4500, Hologic Inc, Waltham, MA) at a median age of 40 days (range, 10 to 115 days) after birth. RESULTS: Expressed as a percentage of whole body mass, bone mass ranged between 0.86% and 1.99%, was similar between girls and boys and correlated positively with birth weight SD (r=0.42; P<0.05) and body weight SD (r=0.35; P<0.05). No difference in bone mass percentage was found between the different types of oral feedings (fortified human milk and preterm formula) or medications studied (corticoids and diuretics). CONCLUSIONS: Whereas prenatal and postnatal weight gain determines the degree of bone mineralization of premature infants, it appears that the type of oral feeding does not affect differently the postnatal bone mineralization of premature infants, when assessed at the moment of discharge.
Jean De Schepper; Filip Cools; Yvan Vandenplas; Olivia Louis
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  41     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-01     Completed Date:  2006-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  230-4     Citation Subset:  IM    
Department of Pediatric Endocrinology, Akademisch Ziekenhuis Vrije Universiteit Brussel, Brussels, Belgium.
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MeSH Terms
Birth Weight / physiology
Body Weight / physiology
Bone Density / drug effects,  physiology*
Bone Development / drug effects,  physiology*
Densitometry / methods
Food, Fortified*
Infant Formula
Infant, Newborn
Infant, Premature / growth & development*
Infant, Very Low Birth Weight / growth & development*
Milk, Human*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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