Document Detail

Whole-body biodistribution and radiation dosimetry of the new cardiac tracer 99mTc-N-DBODC.
MedLine Citation:
PMID:  18632816     Owner:  NLM     Status:  MEDLINE    
Our purpose was to evaluate the safety profile and biodistribution behavior in healthy human volunteers of the new myocardial perfusion tracer bis[(dimethoxypropylphosphanyl)ethyl]ethoxyethylamine N,N'-bis(ethoxyethyl)dithiocarbamato nitrido technetium(V) (99mTc-N-DBODC). METHODS: Ten healthy male volunteers were injected with 99mTc-N-DBODC under both stress and rest conditions. Anterior and posterior planar gamma-camera images were collected at 5, 30, 60, 240, and 1,440 min after injection, with organ uptake quantified by region-of-interest analysis. Tracer kinetics in body fluids were determined by collecting blood and urine samples at different time points. RESULTS: After injection, 99mTc-N-DBODC showed significant accumulation in the myocardium and prolonged retention. Under rest conditions, uptake in the heart, lungs, and liver at 5 min after injection was 1.67% +/- 0.13%, 1.16% +/- 0.07%, and 10.85% +/- 1.72%, respectively, of administered activity. Under stress conditions, heart uptake was significantly higher (2.07% +/- 0.22%). Radioactivity in the liver decreased to 3.64% +/- 0.98% and 2.37% +/- 0.48% at 60 and 240 min, respectively, after injection. This rapid liver clearance led to favorable heart-to-liver ratios, reaching values of 0.74 +/- 0.13 at rest and 1.26 +/- 0.28 during exercise 60 min after tracer administration. Radiation dose estimates were comparable to those obtained with other myocardial perfusion cationic compounds. CONCLUSION: The high uptake in the myocardium and the fast liver washout of 99mTc-N-DBODC will allow SPECT images of the left ventricle to be acquired early and with excellent quality.
Corrado Cittanti; Licia Uccelli; Micol Pasquali; Alessandra Boschi; Claudia Flammia; Elisa Bagatin; Massimiliano Casali; Michael G Stabin; Luciano Feggi; Melchiore Giganti; Adriano Duatti
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-16
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  49     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-01     Completed Date:  2008-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1299-304     Citation Subset:  IM    
Laboratory of Nuclear Medicine and Nuclear Medicine Section, Department of Radiological Sciences, University of Ferrara, Ferrara, Italy.
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MeSH Terms
Heart / radionuclide imaging*
Middle Aged
Organ Specificity
Organophosphorus Compounds / pharmacokinetics*
Organotechnetium Compounds / diagnostic use,  pharmacokinetics*
Radiation Dosage*
Radiopharmaceuticals / diagnostic use,  pharmacokinetics*
Whole Body Imaging
Reg. No./Substance:
0/99mTc-N-DBODC5; 0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals

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