| Whole-body biodistribution and radiation dosimetry of the new cardiac tracer 99mTc-N-DBODC. | |
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MedLine Citation:
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PMID: 18632816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our purpose was to evaluate the safety profile and biodistribution behavior in healthy human volunteers of the new myocardial perfusion tracer bis[(dimethoxypropylphosphanyl)ethyl]ethoxyethylamine N,N'-bis(ethoxyethyl)dithiocarbamato nitrido technetium(V) (99mTc-N-DBODC). METHODS: Ten healthy male volunteers were injected with 99mTc-N-DBODC under both stress and rest conditions. Anterior and posterior planar gamma-camera images were collected at 5, 30, 60, 240, and 1,440 min after injection, with organ uptake quantified by region-of-interest analysis. Tracer kinetics in body fluids were determined by collecting blood and urine samples at different time points. RESULTS: After injection, 99mTc-N-DBODC showed significant accumulation in the myocardium and prolonged retention. Under rest conditions, uptake in the heart, lungs, and liver at 5 min after injection was 1.67% +/- 0.13%, 1.16% +/- 0.07%, and 10.85% +/- 1.72%, respectively, of administered activity. Under stress conditions, heart uptake was significantly higher (2.07% +/- 0.22%). Radioactivity in the liver decreased to 3.64% +/- 0.98% and 2.37% +/- 0.48% at 60 and 240 min, respectively, after injection. This rapid liver clearance led to favorable heart-to-liver ratios, reaching values of 0.74 +/- 0.13 at rest and 1.26 +/- 0.28 during exercise 60 min after tracer administration. Radiation dose estimates were comparable to those obtained with other myocardial perfusion cationic compounds. CONCLUSION: The high uptake in the myocardium and the fast liver washout of 99mTc-N-DBODC will allow SPECT images of the left ventricle to be acquired early and with excellent quality. |
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Authors:
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Corrado Cittanti; Licia Uccelli; Micol Pasquali; Alessandra Boschi; Claudia Flammia; Elisa Bagatin; Massimiliano Casali; Michael G Stabin; Luciano Feggi; Melchiore Giganti; Adriano Duatti |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-16 |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 49 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-01 Completed Date: 2008-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 1299-304 Citation Subset: IM |
Affiliation:
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Laboratory of Nuclear Medicine and Nuclear Medicine Section, Department of Radiological Sciences, University of Ferrara, Ferrara, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Heart / radionuclide imaging* Humans Male Middle Aged Organ Specificity Organophosphorus Compounds / pharmacokinetics* Organotechnetium Compounds / diagnostic use, pharmacokinetics* Radiation Dosage* Radiopharmaceuticals / diagnostic use, pharmacokinetics* Whole Body Imaging |
| Chemical | |
Reg. No./Substance:
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0/99mTc-N-DBODC5; 0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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