| Whole body autoradiography of 5-fluorouracil-6-14C in nude mice bearing murine leukemia cells P388. | |
| | |
MedLine Citation:
|
PMID: 6665233 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Whole body autoradiography of 5-fluorouracil (5-FU)-6-14C intraperitoneally injected to nude mice bearing murine leukemia cells (P388) indicated that absorption of 5-FU from mesenterium to digestive gland and canals was so quick that liver and stomach as well as duodenum had intensive radioactivity as 10 and 30 min after administration. Lower intestine had less radioactivity than duodenum and it was reduced noticeably as time passed. The activity in the kidney at initial stage was distributed throughout the cortex but it was concentrated to transitional zone between cortex and outer medulla at h stage. Lung had moderate activity throughout this experiment. Muscles and central nervous system had little radioactivity. Bone appeared radioactive to some extent. Interestingly, heart and cross section of blood vessels in liver and kidney had not radioactivity indicating that 5-FU was not retained in circulating system. These results were compared with that of uracil-14C and 5-fluorouracil-2-14C described by others. |
| | |
Authors:
|
K Kishida; T Makita |
Related Documents
:
|
17122883 - Hematopoietic cell transplantation for chronic myeloproliferative disorders. 15863213 - Immune evasion strategies of pediatric precursor-b acute lymphoblastic leukemia after a... 15665753 - Effects of hematocrit value on microparticle enzyme immunoassay of tacrolimus concentra... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Radioisotopes Volume: 32 ISSN: 0033-8303 ISO Abbreviation: Radioisotopes Publication Date: 1983 Sep |
Date Detail:
|
Created Date: 1984-03-23 Completed Date: 1984-03-23 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 20010290R Medline TA: Radioisotopes Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 411-5 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Autoradiography* Carbon Radioisotopes / diagnostic use Fluorouracil / administration & dosage, metabolism* Injections, Intraperitoneal Leukemia P388 / metabolism* Leukemia, Experimental / metabolism* Male Mice Mice, Nude Time Factors Tissue Distribution |
| Chemical | |
Reg. No./Substance:
|
0/Carbon Radioisotopes; 51-21-8/Fluorouracil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Measurement of bee venom specific IgG antibody in bee venom hypersensitivity and the relation betwee...
Next Document: Absorption and excretion of suprofen in both sexes of rats, guinea pigs, and rabbits.