Document Detail

Whole-body MR imaging of bone marrow.
MedLine Citation:
PMID:  15950099     Owner:  NLM     Status:  MEDLINE    
In clinical routine, multimodality algorithms, including X-ray, computed tomography, scintigraphy and MRI, are used in case of suspected bone marrow malignancy. Skeletal scintigraphy is widely used to asses metastatic disease to the bone, CT is the technique of choice to assess criteria of osseous destruction and bone stability. MRI is the only imaging technique that allows direct visualization of bone marrow and its components with high spatial resolution. The combination of unenhanced T1-weighted-spin echo- and turbo-STIR-sequences have shown to be most useful for the detection of bone marrow abnormalities and are able to discriminate benign from malignant bone marrow changes. Originally, whole-body MRI bone marrow screening was performed in sequential scanning techniques of five body levels with time consuming coil rearrangement and repositioning of the patient. The introduction of a rolling platform mounted on top of a conventional MRI examination table facilitated whole-body MR imaging and, with the use of fast gradient echo, T1-weighted and STIR-imaging techniques, for the first time allowed whole-body imaging within less than one hour. With the development of parallel imaging techniques (PAT) in combination with global matrix coil concepts, acquisition time could be reduced substantially without compromises in spatial resolution, enabling the implementation of more complex and flexible examination protocols. Whole-body MRI represents a new alternative to the stepwise multimodality concept for the detection of metastatic disease, multiple myeloma and lymphoma of the bone with high diagnostic accuracy.
G P Schmidt; S O Schoenberg; M F Reiser; A Baur-Melnyk
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European journal of radiology     Volume:  55     ISSN:  0720-048X     ISO Abbreviation:  Eur J Radiol     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-13     Completed Date:  2005-11-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  33-40     Citation Subset:  IM    
Institute of Clinical Radiology, University Hospitals Munich/Grosshadern, LMU, Marchioninistr. 15, München 81377, Germany.
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MeSH Terms
Bone Marrow Neoplasms / diagnosis*,  pathology
Bone Neoplasms / diagnosis,  secondary
Diagnosis, Differential
Magnetic Resonance Imaging / instrumentation,  methods*
Neoplasm Metastasis / diagnosis
Sensitivity and Specificity

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