| Whole-brain proton MR spectroscopic imaging of mild-to-moderate traumatic brain injury and correlation with neuropsychological deficits. | |
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MedLine Citation:
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PMID: 20201668 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Changes in the distribution of the magnetic resonance (MR)-observable brain metabolites N-acetyl aspartate (NAA), total choline (Cho), and total creatine (Cre), following mild-to-moderate closed-head traumatic brain injury (mTBI) were evaluated using volumetric proton MR spectroscopic imaging (MRSI). Studies were carried out during the subacute time period following injury, and associations of metabolite indices with neuropsychological test (NPT) results were evaluated. Twenty-nine subjects with mTBI and Glasgow Coma Scale (GCS) scores of 10-15 were included. Differences in individual metabolite and metabolite ratio distributions relative to those of age-matched control subjects were evaluated, as well as analyses by hemispheric lobes and tissue types. Primary findings included a widespread decrease of NAA and NAA/Cre, and increases of Cho and Cho/NAA, within all lobes of the TBI subject group, and with the largest differences seen in white matter. Examination of the association between all of the metabolite measures and the NPT scores found the strongest negative correlations to occur in the frontal lobe and for Cho/NAA. No significant correlations were found between any of the MRSI or NPT measures and the GCS. These results demonstrate that significant and widespread alterations of brain metabolites occur as a result of mild-to-moderate TBI, and that these measures correlate with measures of cognitive performance. |
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Authors:
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Varan Govind; Stuart Gold; Krithica Kaliannan; Gaurav Saigal; Steven Falcone; Kristopher L Arheart; Leo Harris; Jonathan Jagid; Andrew A Maudsley |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of neurotrauma Volume: 27 ISSN: 1557-9042 ISO Abbreviation: J. Neurotrauma Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-30 Completed Date: 2010-06-17 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 8811626 Medline TA: J Neurotrauma Country: United States |
Other Details:
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Languages: eng Pagination: 483-96 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Miami School of Medicine, Miami, Florida 33136, USA. VGovind@med.miami.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aspartic Acid / analogs & derivatives, analysis, metabolism Biological Markers / analysis, metabolism Brain / metabolism*, pathology, physiopathology Brain Injuries / metabolism*, pathology, physiopathology Choline / analysis, metabolism Cognition Disorders / metabolism*, pathology, physiopathology Creatine / analysis, metabolism Diffuse Axonal Injury / metabolism, pathology, physiopathology Disability Evaluation Female Frontal Lobe / metabolism, pathology, physiopathology Glasgow Coma Scale Humans Magnetic Resonance Spectroscopy / methods* Male Nerve Fibers, Myelinated / metabolism, pathology Neuropsychological Tests Wallerian Degeneration / metabolism, pathology, physiopathology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01EB000822/EB/NIBIB NIH HHS; R01NS055107/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline; 997-55-7/N-acetylaspartate |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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