| Whole-Body Distribution and Radiation Dosimetry of (68)Ga-NOTA-RGD, a Positron Emission Tomography Agent for Angiogenesis Imaging. | |
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MedLine Citation:
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PMID: 22149685 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract (68)Ga labeled NOTA-RGD was a recently developed positron emission tomography (PET) radiotracer for the visualization of angiogenesis, and is regarded as a promising imaging agent for cancer and several other disorders. In this study, we investigated the whole-body distribution and radiation dosimetry of (68)Ga-NOTA-RGD in humans. Ten cancer patients (53.7±13.5 years; 61.5±7.4 kg) participated in this study. PET scans were performed using a PET/computed tomography (scanner in three-dimensional mode). After an intravenous injection of 172.4±20.5 MBq of (68)Ga-NOTA-RGD, eight serial whole-body scans were performed during 90 minutes. Volumes of interest were drawn manually over the entire volumes of the urinary bladder, the gallbladder, heart, kidneys, liver, lungs, pancreas, spleen, and stomach. Time-activity curves were obtained from serial PET scan data. Residence times were calculated from areas under curve of time-activity curves and used as input to the OLINDA/EXM 1.1 software. The uptake of (68)Ga-NOTA-RGD was highest in the kidneys and urinary bladder. Radiation doses to kidneys and urinary bladder were 71.6±28.4 μGy/MBq and 239.6±56.6 μGy/MBq. Mean effective doses were 25.0±4.4 μSv/MBq using International Commission of Radiation Protection (ICRP) publication 60 and 22.4±3.8 μSv/MBq using ICRP publication 103 weighting factor. We evaluated the radiation dosimetry of (68)Ga labeled NOTA-RGD, which has an acceptable effective radiation dose. |
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Authors:
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Joong Hyun Kim; Jae Sung Lee; Keon Wook Kang; Ho-Young Lee; Sae-Won Han; Tae-You Kim; Yun-Sang Lee; Jae Min Jeong; Dong Soo Lee |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-9 |
Journal Detail:
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Title: Cancer biotherapy & radiopharmaceuticals Volume: - ISSN: 1557-8852 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9605408 Medline TA: Cancer Biother Radiopharm Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1 Department of Nuclear Medicine, Seoul National University College of Medicine , Seoul, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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