| Whole Body Biodistribution and Radiation Dosimetry in Humans of a New PET Ligand, [(18)F]-FEPPA, to Image Translocator Protein (18 kDa). | |
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MedLine Citation:
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PMID: 22895910 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: [(18)F]-FEPPA is a translocator protein (18 kDa, TSPO) positron emission tomography (PET) radiotracer. Radiation dosimetry was estimated from the whole body biodistribution, taking into consideration TSPO rs6971 (Ala147Thr) polymorphism. PROCEDURES: [(18)F]-FEPPA whole body PET scans were acquired for six healthy subjects. Time-activity curves were generated from regions of interest of nine organs, from which normalized accumulated activities were calculated and thus internal dose, using OLINDA/EXM 1.1. Genotyping of rs6971, associated with high- and low-affinity [(18)F]-FEPPA binding (high-affinity binder (HAB) and low-affinity binder (LAB)), was performed. RESULTS: Five subjects exhibited the C/C (HAB) allele, and the other carried the minor allele T/T (LAB). The LAB whole body biodistribution showed highest radioactivity accumulation in bladder, whereas in HABs, the spleen received the highest dose. The effective dose of the single LAB (16.3 μSv/MBq) was 23 % less than the mean of the HABs (21.0 ± 2.9 μSv/MBq). When including all subjects, the effective dose was 20.2 ± 3.0 μSv/MBq. CONCLUSIONS: [(18)F]-FEPPA radiation dose is consistent with other (18)F-labeled radioligands and the Ala147Thr genotype agreed with [(18)F]-FEPPA distribution. |
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Authors:
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Romina Mizrahi; Pablo M Rusjan; Irina Vitcu; Alvina Ng; Alan A Wilson; Sylvain Houle; Peter M Bloomfield |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-16 |
Journal Detail:
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Title: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging Volume: - ISSN: 1860-2002 ISO Abbreviation: Mol Imaging Biol Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101125610 Medline TA: Mol Imaging Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Vivian M. Rakoff PET Centre, Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), 250 College Street, Toronto, Ontario, Canada, M5T 1R8. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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