| Who tangos with GOA?-Use of Gene Ontology Annotation (GOA) for biological interpretation of '-omics' data and for validation of automatic annotation tools. | |
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MedLine Citation:
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PMID: 15972001 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The number of large-scale experimental datasets generated from high-throughput technologies has grown rapidly. Biological knowledge resources such as the Gene Ontology Annotation (GOA) database, which provides high-quality functional annotation to proteins within the UniProt Knowledgebase, can play an important role in the analysis of such data. The integration of GOA with analytical tools has proved to aid the clustering, annotation and biological interpretation of such large expression datasets. GOA is also useful in the development and validation of automated annotation tools, in particular text-mining systems. The increasing interest in GOA highlights the great potential of this freely available resource to assist both the biological research and bioinformatics communities. |
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Authors:
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Vivian Lee; Evelyn Camon; Emily Dimmer; Daniel Barrell; Rolf Apweiler |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: In silico biology Volume: 5 ISSN: 1386-6338 ISO Abbreviation: In Silico Biol. (Gedrukt) Publication Date: 2005 |
Date Detail:
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Created Date: 2005-06-23 Completed Date: 2005-09-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9815902 Medline TA: In Silico Biol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 5-8 Citation Subset: IM |
Affiliation:
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EMBL Outstation-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. goa@ebi.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Computational Biology / methods* Databases, Genetic Databases, Protein Gene Expression* Humans Models, Genetic* Proteome / chemistry Proteomics / methods Terminology as Topic* Transcription, Genetic |
| Grant Support | |
ID/Acronym/Agency:
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HG-O2273/HG/NHGRI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Proteome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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