Document Detail

Who gets missed: coverage in a provincial newborn screening program for metabolic disease.
MedLine Citation:
PMID:  9685466     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine coverage of the newborn screening program (NSP) for metabolic disease in Alberta, Canada, and to determine reasons for not being screened. STUDY DESIGN: Coverage was estimated by deterministic matching of live birth registration data with newborn screening data for the year 1992. Demographic characteristics of not-matched infants were compared with good-match infants using logistic regression. RESULTS: For 42 392 live births, there were 41 553 screening records, of which 40 593 infants were very good matches to NSP records. Another 960 were possible matches. A total of 839 infants were not matched at all, and coverage was estimated at 98.0%. Determinants of infant not-matched status were death in week 1 (adjusted odds ratio [OR]: 383); birth weight of <1500 g (adjusted OR: 18.9) or between 1500 and 2500 g (adjusted OR: 3.2); having a mother who was single (adjusted OR: 2.7) or formerly married (adjusted OR: 12.9); or being born out of hospital (OR: 19. 2). The calculated 98% coverage is close to an estimate of 98.3% made by the NSP comparing total births with initial screenings. CONCLUSION: The matched data give insight as to who was missed and point to the need for closer attention for infants at greater risk of not being screened for metabolic disease.
D W Spady; L D Saunders; F Bamforth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  102     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-08-12     Completed Date:  1998-08-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  e21     Citation Subset:  IM    
Departments of Pediatrics, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada.
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MeSH Terms
Alberta / epidemiology
Birth Weight
Infant, Newborn
Logistic Models
Maternal Age
Metabolism, Inborn Errors / diagnosis,  epidemiology*,  prevention & control
Neonatal Screening / standards,  utilization*
Odds Ratio
Practice Guidelines as Topic
Predictive Value of Tests
Risk Factors
Utilization Review

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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