Document Detail


Who gets missed: coverage in a provincial newborn screening program for metabolic disease.
MedLine Citation:
PMID:  9685466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine coverage of the newborn screening program (NSP) for metabolic disease in Alberta, Canada, and to determine reasons for not being screened. STUDY DESIGN: Coverage was estimated by deterministic matching of live birth registration data with newborn screening data for the year 1992. Demographic characteristics of not-matched infants were compared with good-match infants using logistic regression. RESULTS: For 42 392 live births, there were 41 553 screening records, of which 40 593 infants were very good matches to NSP records. Another 960 were possible matches. A total of 839 infants were not matched at all, and coverage was estimated at 98.0%. Determinants of infant not-matched status were death in week 1 (adjusted odds ratio [OR]: 383); birth weight of <1500 g (adjusted OR: 18.9) or between 1500 and 2500 g (adjusted OR: 3.2); having a mother who was single (adjusted OR: 2.7) or formerly married (adjusted OR: 12.9); or being born out of hospital (OR: 19. 2). The calculated 98% coverage is close to an estimate of 98.3% made by the NSP comparing total births with initial screenings. CONCLUSION: The matched data give insight as to who was missed and point to the need for closer attention for infants at greater risk of not being screened for metabolic disease.
Authors:
D W Spady; L D Saunders; F Bamforth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  102     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-08-12     Completed Date:  1998-08-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  e21     Citation Subset:  IM    
Affiliation:
Departments of Pediatrics, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada.
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MeSH Terms
Descriptor/Qualifier:
Alberta / epidemiology
Birth Weight
Humans
Infant, Newborn
Logistic Models
Marriage
Maternal Age
Metabolism, Inborn Errors / diagnosis,  epidemiology*,  prevention & control
Neonatal Screening / standards,  utilization*
Odds Ratio
Practice Guidelines as Topic
Predictive Value of Tests
Risk Factors
Utilization Review

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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