Document Detail

Who will drop out and who will drop in: exercise adherence in a randomized clinical trial among patients receiving active cancer treatment.
MedLine Citation:
PMID:  22228393     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Adherence has significantly affected the efficacy of a randomized clinical trial (RCT) to test exercise interventions.
OBJECTIVE: The aims of this study were to analyze exercise-related adherence patterns among patients receiving active cancer treatment and to identify factors related to exercise adherence and contamination in both the intervention and control groups.
METHODS: This is a secondary analysis of data from an RCT of a home-based walking intervention for patients receiving active cancer treatment. Hierarchical Poisson regression analysis was used to identify factors related to exercise adherence and exercise contamination in the exercise intervention and control groups.
RESULTS: A total of 126 patients finished the study. Exercise adherence rate in the intervention group was 32.35%, whereas exercise contamination rate in the control group was 12.07%. Independent predictors of adherence for the exercise group were baseline physical fitness, pretreatment fatigue level, treatment-related mood disturbance, and marital status (P < .01); exercise history significantly predicted exercise contamination (P < .00) in the control group.
CONCLUSION: Adherence remains an issue in an exercise RCT among patients on active cancer treatment. Adherence is related to symptom, physical function, and exercise history.
IMPLICATIONS FOR PRACTICE: Exercise researchers should consider stratifying samples based on pretreatment variables found to be significantly associated with outcome variables in this study to reduce confounding effects. Oncology clinicians can use the study findings to appropriately tailor strategies to encourage exercise adherence among patients receiving active cancer treatment so that these patients can receive the known benefits of exercise.
Jingjing Shang; Jennifer Wenzel; Sharon Krumm; Kathleen Griffith; Kerry Stewart
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer nursing     Volume:  35     ISSN:  1538-9804     ISO Abbreviation:  Cancer Nurs     Publication Date:    2012 Jul-Aug
Date Detail:
Created Date:  2012-06-15     Completed Date:  2012-10-12     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  7805358     Medline TA:  Cancer Nurs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  312-22     Citation Subset:  IM; N    
School of Nursing, Columbia University, New York, NY 10032, USA.
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MeSH Terms
Exercise Therapy*
Fatigue / etiology
Middle Aged
Neoplasms / complications,  therapy*
Patient Compliance / statistics & numerical data*
Patient Dropouts*
Poisson Distribution
Regression Analysis
Risk Factors
Grant Support
R01 NR004991-01A2/NR/NINR NIH HHS; R01 NR004991-02/NR/NINR NIH HHS; R01 NR004991-03/NR/NINR NIH HHS; R01 NR004991-04/NR/NINR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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