Document Detail


White monkey syndrome and presumptive copper deficiency in wild savannah baboons.
MedLine Citation:
PMID:  21898510     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In immature wild savannah baboons (Papio cynocephalus), we observed symptoms consistent with copper (Cu) deficiency and, more specifically, with a disorder referred to as white monkey syndrome (WMS) in laboratory primates. The objectives of this study were to characterize this pathology, and test three hypotheses that (1) Cu deficiency may have been induced by zinc (Zn) toxicity, (2) it may have been induced by molybdenum (Mo) toxicity, and (3) cumulative rainfall during the perinatal period and particularly during gestation is an ecological factor distinguishing infants afflicted with WMS from non-WMS infants. During 2001-2009, we observed 22 instances of WMS out of a total 377 live births in the study population. Visible symptoms exhibited by WMS infants included whitening of the animal's fur and/or impaired mobility characterized by an apparent "stiffening" of the hindlimbs. Occurrence of WMS did not vary significantly by gender. However, among individuals that survived at least 180 days, WMS males had a significantly lower survivorship probability than non-WMS males. Zn/Cu ratios assessed from hair samples of adult female baboons were higher in females who had produced at least one WMS offspring relative to females who had not had a WMS offspring. This was true even when the hair sample was collected long after the birth of the female's afflicted infant. We consider this potentially indicative of a robust tendency for low Cu levels induced by elevated Zn intake in some individuals. No significant differences of Mo/Cu ratios were observed. Cumulative rainfall during gestation (∼179 days) was 50% lower for WMS infants relative to non-WMS infants. In contrast, rainfall for the two classes of infants did not differ in the 180 days before conception or in the 180 days following birth. This finding highlights the importance of prenatal ecological conditions in healthy fetal development with regard to WMS.
Authors:
A Catherine Markham; Laurence R Gesquiere; Jean-Philippe Bellenger; Susan C Alberts; Jeanne Altmann
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-09-06
Journal Detail:
Title:  American journal of primatology     Volume:  73     ISSN:  1098-2345     ISO Abbreviation:  Am. J. Primatol.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-09-28     Completed Date:  2012-01-10     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  8108949     Medline TA:  Am J Primatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1160-8     Citation Subset:  IM    
Copyright Information:
© 2011 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Copper / deficiency*
Deficiency Diseases / etiology,  veterinary*
Ecosystem
Female
Hair / chemistry
Kenya
Male
Molybdenum / analysis,  toxicity*
Papio cynocephalus / metabolism*
Rain
Zinc / analysis,  toxicity*
Grant Support
ID/Acronym/Agency:
R01 AG034513/AG/NIA NIH HHS; R01AG034513-01/AG/NIA NIH HHS; R24 HD047879/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
789U1901C5/Copper; 81AH48963U/Molybdenum; J41CSQ7QDS/Zinc
Comments/Corrections

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