| White matter volume and concentration reductions in adolescents with history of very preterm birth: a voxel-based morphometry study. | |
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MedLine Citation:
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PMID: 16809052 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Very preterm birth (VPTB) is an important risk factor for white matter (WM) damage. We used voxel-based morphometry (VBM) to examine regional WM brain abnormalities in 50 adolescents with antecedents of very preterm birth (VPTB) without evidence of WM damage on T2-weighted MRI. This group was compared with a group of 50 subjects born at term and matched for age, handedness and socio-cultural status. We also examined the relationship between WM changes and gestational age (GA) and weight (GW) at birth in VPTB subjects. Both modulated and unmodulated VBM analyses showed significant abnormalities in several WM brain regions in the VPTB group, involving all the cerebral lobes. However, density analyses (unmodulated data) mainly identified periventricular damage and the involvement of the longitudinal fascicles while volume analyses (modulated data) detected WM decreases in regions distant from the ventricular system, located at the origin and end of the long fascicles. A significant correlation was found between WM decreases and both GA and GW in various brain regions: the lower the GA and GW, the lower the WM integrity. This study supports the current view that widespread white matter impairment is associated with immature birth. |
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Authors:
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Mónica Giménez; Carme Junqué; Ana Narberhaus; Núria Bargalló; Francesc Botet; Josep Maria Mercader |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-06-30 |
Journal Detail:
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Title: NeuroImage Volume: 32 ISSN: 1053-8119 ISO Abbreviation: Neuroimage Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-11 Completed Date: 2006-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9215515 Medline TA: Neuroimage Country: United States |
Other Details:
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Languages: eng Pagination: 1485-98 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, University of Barcelona, and Department of Obstetrics and Gynecology, Pediatrics, Radiology and Physics Medicine, Hospital Clinic, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Birth Weight / physiology Brain / pathology* Female Functional Laterality / physiology Gestational Age Humans Image Processing, Computer-Assisted Infant, Newborn Infant, Premature / physiology*, psychology Intelligence Tests Magnetic Resonance Imaging Male |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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