Document Detail

White matter reduction in patients with schizophrenia as revealed by voxel-based morphometry: an activation likelihood estimation meta-analysis.
MedLine Citation:
PMID:  19744536     Owner:  NLM     Status:  MEDLINE    
Schizophrenia is thought to be a mental disorder caused by the disconnection of brain regions. Cumulative evidence of white matter deficit in patients with schizophrenia has been reported using voxel-based morphometry (VBM), but these studies have not been quantitatively reviewed. In the study reported herein, we used activation likelihood estimation (ALE) analysis to quantitatively estimate focal white matter abnormalities in patients with schizophrenia. Seventeen studies that compared the white matter deficit of patients with schizophrenia and healthy controls were ascertained. The frontal white matter regions and internal capsule revealed consistent white matter reduction in patient groups relative to healthy controls, suggesting a clear focal white matter deficit in patients with schizophrenia. These results support the macro-circuit theory of white matter change in schizophrenia.
Xin Di; Raymond C K Chan; Qi-yong Gong
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review     Date:  2009-09-07
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  33     ISSN:  1878-4216     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-10     Completed Date:  2010-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  1390-4     Citation Subset:  IM    
Neuropsychology and Applied Cognitive Neuroscience Laboratory, Department of Psychology, Sun Yat-Sen University, Guangzhou, China.
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MeSH Terms
Brain Mapping
Image Processing, Computer-Assisted / methods
Likelihood Functions
Magnetic Resonance Imaging / methods
Nerve Fibers, Myelinated / pathology*
Neural Pathways / pathology
Schizophrenia / pathology*

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