Document Detail

White matter microstructural alterations in migraine: A diffusion-weighted MRI study.
MedLine Citation:
PMID:  22244439     Owner:  NLM     Status:  Publisher    
Migraine is a common and disabling neurological disease. The pathomechanism that underlies the disorder is not entirely understood, and reliable biomarkers are missing. In the current analysis we looked for microstructural alterations of the brain white matter in migraine patients by means of diffusion-weighted magnetic resonance imaging. The measurements were carried out with a novel approach based on fine-tuned nonlinear registration and nonparametric permutation test in an alignment-invariant tract representation (Tract-Based Spatial Statistics). We found reduced fractional anisotropy in the right frontal white matter cluster of migraine patients. In the same region we also found increased mean diffusivity and increased radial diffusivity. The probabilistic tractography showed connection of this cluster to other parts of the pain network (orbitofrontal cortex, insula, thalamus, dorsal midbrain). We speculate that these findings reflect maladaptive plastic changes or white matter disintegration.
Nikoletta Szabó; Zsigmond Tamás Kincses; Arpád Párdutz; János Tajti; Délia Szok; Bernadett Tuka; András Király; Magor Babos; Erika Vörös; Giuseppe Bomboi; Francesco Orzi; László Vécsei
Related Documents :
21321269 - Dual-biomarker imaging of regional cerebral amyloid load and neuronal activity in demen...
25449739 - Gray matter myelination of 1555 human brains using partial volume corrected mri images.
20213699 - Cleft lip and palate results from hedgehog signaling antagonism in the mouse: phenotypi...
20624989 - Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus.
2685879 - The spectrum of heterotaxic syndromes.
16847599 - Imaging the fetal spine using in utero mr: diagnostic accuracy and impact on management.
23438659 - Prevalence of spinal meningeal cyst in the sacrum.
2792899 - Clinical value of computerized tomography (ct) in assessment of recurrent uterine cancers.
24920419 - Nanodots: ultrasmall nagdf4 nanodots for efficient mr angiography and atherosclerotic p...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-11
Journal Detail:
Title:  Pain     Volume:  -     ISSN:  1872-6623     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7508686     Medline TA:  Pain     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Radioactive seed migration after transperineal interstitial prostate brachytherapy and associated de...
Next Document:  Effects of mitochondrial poisons on the neuropathic pain produced by the chemotherapeutic agents, pa...