Document Detail

White matter integrity is reduced in bulimia nervosa.
MedLine Citation:
PMID:  23354827     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate brain white matter (WM) functionality in bulimia nervosa (BN) in relation to anxiety.
METHOD: Twenty-one control women (CW, mean age 27 ± 7 years) and 20 BN women (mean age 25 ± 5 years) underwent brain diffusion tensor imaging to measure fractional anisotropy (FA; an indication of WM axon integrity) and the apparent diffusion coefficient (ADC; reflecting WM cell damage).
RESULTS: FA was decreased in BN in the bilateral corona radiata extending into the posterior limb of the internal capsule, the corpus callosum, the right sub-insular WM, and right fornix. In CW but not BN, trait anxiety correlated negatively with fornix, corpus callosum, and left corona radiata FA. ADC was increased in BN compared with CW in the bilateral corona radiata, corpus callosum, inferior fronto-occipital, and uncinate fasciculus. Alterations in BN WM functionality were not due to structural brain alterations.
DISCUSSION: WM integrity is disturbed in BN, especially in the corona radiata, which has been associated with taste and brain reward processing. Whether this is a premorbid condition or an effect from the illness is yet uncertain. The relationships between WM FA and trait anxiety in CW but not BN may suggest that altered WM functionality contributes to high anxious traits in BN.
Lisa N Mettler; Megan E Shott; Tamara Pryor; Tony T Yang; Guido K W Frank
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-28
Journal Detail:
Title:  The International journal of eating disorders     Volume:  46     ISSN:  1098-108X     ISO Abbreviation:  Int J Eat Disord     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-15     Completed Date:  2013-09-17     Revised Date:  2014-10-24    
Medline Journal Info:
Nlm Unique ID:  8111226     Medline TA:  Int J Eat Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  264-73     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
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MeSH Terms
Brain / pathology*
Brain Mapping
Bulimia Nervosa / pathology*
Corpus Callosum / pathology*
Diffusion Tensor Imaging
Fornix, Brain / pathology*
Image Processing, Computer-Assisted
Nerve Fibers, Myelinated / pathology*
Grant Support
K23 MH080135/MH/NIMH NIH HHS; K23 MH080135-01A2/MH/NIMH NIH HHS; R25 MH080859/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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