Document Detail


White matter imaging contributes to the multimodal diagnosis of frontotemporal lobar degeneration.
MedLine Citation:
PMID:  22592372     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the distribution of white matter (WM) disease in frontotemporal lobar degeneration (FTLD) and Alzheimer disease (AD) and to evaluate the relative usefulness of WM and gray matter (GM) for distinguishing these conditions in vivo.
METHODS: Patients were classified as having FTLD (n = 50) or AD (n = 42) using autopsy-validated CSF values of total-tau:β-amyloid (t-tau:Aβ(1-42)) ratios. Patients underwent WM diffusion tensor imaging (DTI) and volumetric MRI of GM. We employed tract-specific analyses of WM fractional anisotropy (FA) and whole-brain GM density analyses. Individual patient classification was performed using receiver operator characteristic (ROC) curves with FA, GM, and a combination of the 2 modalities.
RESULTS: Regional FA and GM were significantly reduced in FTLD and AD relative to healthy seniors. Direct comparisons revealed significantly reduced FA in the corpus callosum in FTLD relative to AD. GM analyses revealed reductions in anterior temporal cortex for FTLD relative to AD, and in posterior cingulate and precuneus for AD relative to FTLD. ROC curves revealed that a multimodal combination of WM and GM provide optimal classification (area under the curve = 0.938), with 87% sensitivity and 83% specificity.
CONCLUSIONS: FTLD and AD have significant WM and GM defects. A combination of DTI and volumetric MRI modalities provides a quantitative method for distinguishing FTLD and AD in vivo.
Authors:
C T McMillan; C Brun; S Siddiqui; M Churgin; D Libon; P Yushkevich; H Zhang; A Boller; J Gee; M Grossman
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-05-16
Journal Detail:
Title:  Neurology     Volume:  78     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-29     Completed Date:  2012-07-30     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1761-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology, University of Pennsylvania, PA, USA. mcmillac@mail.med.upenn.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / diagnosis*
Anisotropy
Brain / pathology*
Cerebral Cortex / pathology
Diffusion Magnetic Resonance Imaging*
Diffusion Tensor Imaging
Female
Frontotemporal Lobar Degeneration / diagnosis*
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Neuropsychological Tests
ROC Curve
Sensitivity and Specificity
Grant Support
ID/Acronym/Agency:
AG015116/AG/NIA NIH HHS; AG027785/AG/NIA NIH HHS; AG032953/AG/NIA NIH HHS; AG037376/AG/NIA NIH HHS; AG17586/AG/NIA NIH HHS; F32 HD060406/HD/NICHD NIH HHS; HD060406/HD/NICHD NIH HHS; K25 AG027785/AG/NIA NIH HHS; NS044266/NS/NINDS NIH HHS; NS053488/NS/NINDS NIH HHS; NS065347/NS/NINDS NIH HHS; P01 AG017586/AG/NIA NIH HHS; P01 AG032953/AG/NIA NIH HHS; P50 NS053488/NS/NINDS NIH HHS; R01 AG015116/AG/NIA NIH HHS; R01 AG037376/AG/NIA NIH HHS; R01 NS044266/NS/NINDS NIH HHS; R01 NS065347/NS/NINDS NIH HHS
Comments/Corrections

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