Document Detail


White-matter disease in 18q deletion (18q-) syndrome: magnetic resonance spectroscopy indicates demyelination or increased myelin turnover rather than dysmyelination.
MedLine Citation:
PMID:  15645149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Proton magnetic resonance spectroscopic data ((1)H-MR spectroscopy) of patients with 18q deletion syndrome have not yet been reported. (1)H-MR spectroscopy, performed in an affected 2-year-old girl with markedly delayed neuromotor development and typical supratentorial white-matter disease (WMD), showed an increase of choline and alpha-glutamate concentrations. Eight months later, simultaneously with clinical improvement, alpha-glutamate had normalised whereas choline remained slightly increased. Active demyelination or increased myelin turnover might contribute to the hitherto unexplained WMD of this rare disorder.
Authors:
M Häusler; D Anhuf; H Schüler; V T Ramaekers; A Thron; K Zerres; W Möller-Hartmann
Related Documents :
23190289 - Pseudoprogression in high-grade glioma.
18653689 - Nectar formation and floral nectary anatomy of anigozanthos flavidus: a combined magnet...
3379399 - High-resolution proton magnetic resonance spectroscopy of rabbit brain: regional metabo...
12457379 - Dextro-amphetamine increases phosphoinositol cycle activity in volunteers: an mrs study.
8159259 - Analysis of magnetic resonance spectra by mole percent: comparison to absolute units.
2701569 - 19f mrs studies of fluoropyrimidine chemotherapy. a review.
22691269 - Detection of cervical lymph node metastasis in head and neck cancer patients with clini...
23190289 - Pseudoprogression in high-grade glioma.
21135879 - Assessment of stone composition in the management of urinary stones.
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-01-11
Journal Detail:
Title:  Neuroradiology     Volume:  47     ISSN:  0028-3940     ISO Abbreviation:  Neuroradiology     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-02-08     Completed Date:  2005-05-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302751     Medline TA:  Neuroradiology     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  83-6     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University Hospital of Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany. haeusler@rwth-aachen.de
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aspartic Acid / analogs & derivatives*,  analysis
Brain Diseases / metabolism*
Choline / analysis
Chromosome Deletion*
Chromosomes, Human, Pair 18 / genetics*
Demyelinating Diseases / diagnosis*
Female
Follow-Up Studies
Glutamic Acid / analysis
Humans
Infant
Inositol / analysis
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy / diagnostic use*
Myelin Sheath / metabolism*
Chemical
Reg. No./Substance:
56-84-8/Aspartic Acid; 56-86-0/Glutamic Acid; 62-49-7/Choline; 6917-35-7/Inositol; 997-55-7/N-acetylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pelvic floor muscle evaluation in incontinent patients.
Next Document:  Image-guided microneurosurgical management of small cerebral arteriovenous malformations: the value ...