| White matter abnormalities in methcathinone abusers with an extrapyramidal syndrome. | |
| | |
MedLine Citation:
|
PMID: 21036949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We examined white matter abnormalities in patients with a distinctive extrapyramidal syndrome due to intravenous methcathinone (ephedrone) abuse. We performed diffusion tensor imaging in 10 patients and 15 age-matched controls to assess white matter structure across the whole brain. Diffuse significant decreases in white matter fractional anisotropy, a diffusion tensor imaging metric reflecting microstructural integrity, occurred in patients compared with controls. In addition, we identified two foci of severe white matter abnormality underlying the right ventral premotor cortex and the medial frontal cortex, two cortical regions involved in higher-level executive control of motor function. Paths connecting different cortical regions with the globus pallidus, the nucleus previously shown to be abnormal on structural imaging in these patients, were generated using probabilistic tractography. The fractional anisotropy within all these tracts was lower in the patient group than in controls. Finally, we tested for a relationship between white matter integrity and clinical outcome. We identified a region within the left corticospinal tract in which lower fractional anisotropy was associated with greater functional deficit, but this region did not show reduced fractional anisotropy in the overall patient group compared to controls. These patients have widespread white matter damage with greatest severity of damage underlying executive motor areas. |
| | |
Authors:
|
Ainars Stepens; Charlotte Jane Stagg; Ardis Platkajis; Marie-Hélène Boudrias; Heidi Johansen-Berg; Michael Donaghy |
Related Documents
:
|
19800899 - The spatial encoding of body parts in patients with neglect and neurologically unimpair... 17457029 - Metabolic correlates of brain reserve in dementia with lewy bodies: an fdg pet study. 8234569 - Neuropathological basis for drawing disability (constructional apraxia) in alzheimer's ... 9151009 - Neurobiological findings in first admission patients with schizophrenia or schizophreni... 3415199 - Asymbolia for pain: a sensory-limbic disconnection syndrome. 12088079 - Alpha[11c] methyl-l-typtophan positron emission tomography in patients with alternating... 20850799 - An immunohistochemical study of ubiquitin in the skin of sporadic amyotrophic lateral s... 19826819 - Uveitis in celiac disease with an excellent response to gluten-free diet: third case de... 3105679 - Partial splenic embolisation for hypersplenism of thalassaemia major: five year follow up. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-29 |
Journal Detail:
|
Title: Brain : a journal of neurology Volume: 133 ISSN: 1460-2156 ISO Abbreviation: Brain Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-12-03 Completed Date: 2011-01-07 Revised Date: 2011-06-01 |
Medline Journal Info:
|
Nlm Unique ID: 0372537 Medline TA: Brain Country: England |
Other Details:
|
Languages: eng Pagination: 3676-84 Citation Subset: AIM; IM |
Affiliation:
|
Department of Neurology, Riga Stradins University, Riga 1007, Latvia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Basal Ganglia Diseases / chemically induced, pathology* Brain / pathology* Data Interpretation, Statistical Diffusion Magnetic Resonance Imaging Disability Evaluation Extrapyramidal Tracts / pathology Female Globus Pallidus / pathology Humans Male Manganese Poisoning / etiology, pathology Middle Aged Parkinson Disease, Secondary / chemically induced, psychology Propiophenones* Substance Abuse, Intravenous Substance-Related Disorders / pathology* |
| Grant Support | |
ID/Acronym/Agency:
|
078204//Wellcome Trust; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
|
0/Propiophenones; 5650-44-2/monomethylpropion |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An exo-{alpha}-sialidase from bifidobacteria involved in the degradation of sialyloligosaccharides i...
Next Document: Glutaredoxin and thioredoxin can be involved in producing the pharmacologically active metabolite of...