Document Detail


White matter abnormalities in methcathinone abusers with an extrapyramidal syndrome.
MedLine Citation:
PMID:  21036949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined white matter abnormalities in patients with a distinctive extrapyramidal syndrome due to intravenous methcathinone (ephedrone) abuse. We performed diffusion tensor imaging in 10 patients and 15 age-matched controls to assess white matter structure across the whole brain. Diffuse significant decreases in white matter fractional anisotropy, a diffusion tensor imaging metric reflecting microstructural integrity, occurred in patients compared with controls. In addition, we identified two foci of severe white matter abnormality underlying the right ventral premotor cortex and the medial frontal cortex, two cortical regions involved in higher-level executive control of motor function. Paths connecting different cortical regions with the globus pallidus, the nucleus previously shown to be abnormal on structural imaging in these patients, were generated using probabilistic tractography. The fractional anisotropy within all these tracts was lower in the patient group than in controls. Finally, we tested for a relationship between white matter integrity and clinical outcome. We identified a region within the left corticospinal tract in which lower fractional anisotropy was associated with greater functional deficit, but this region did not show reduced fractional anisotropy in the overall patient group compared to controls. These patients have widespread white matter damage with greatest severity of damage underlying executive motor areas.
Authors:
Ainars Stepens; Charlotte Jane Stagg; Ardis Platkajis; Marie-Hélène Boudrias; Heidi Johansen-Berg; Michael Donaghy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-29
Journal Detail:
Title:  Brain : a journal of neurology     Volume:  133     ISSN:  1460-2156     ISO Abbreviation:  Brain     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-03     Completed Date:  2011-01-07     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0372537     Medline TA:  Brain     Country:  England    
Other Details:
Languages:  eng     Pagination:  3676-84     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology, Riga Stradins University, Riga 1007, Latvia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Basal Ganglia Diseases / chemically induced,  pathology*
Brain / pathology*
Data Interpretation, Statistical
Diffusion Magnetic Resonance Imaging
Disability Evaluation
Extrapyramidal Tracts / pathology
Female
Globus Pallidus / pathology
Humans
Male
Manganese Poisoning / etiology,  pathology
Middle Aged
Parkinson Disease, Secondary / chemically induced,  psychology
Propiophenones*
Substance Abuse, Intravenous
Substance-Related Disorders / pathology*
Grant Support
ID/Acronym/Agency:
078204//Wellcome Trust; 090955//Wellcome Trust; //Wellcome Trust
Chemical
Reg. No./Substance:
0/Propiophenones; 5650-44-2/monomethylpropion
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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