| White-matter abnormalities in adolescents with long-term inhalant and cannabis use: a diffusion magnetic resonance imaging study. | |
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MedLine Citation:
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PMID: 20731960 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: There is growing evidence that inhalants are neurotoxic to white matter, yet limited work has been conducted to investigate the neurobiologic effects of long-term exposure among adolescent users, despite inhalant use being most prominent during this developmental period. METHODS: We used diffusion tensor imaging to examine white-matter integrity in 11 adolescents who used inhalants, 11 matched cannabis users and 8 drug-naive controls. RESULTS: Although both groups of drug users had white-matter abnormalities (i.e., lower fractional anisotropy), abnormalities were more pronounced in the inhalant group, particularly among early-onset users. LIMITATIONS: The findings of this study should be considered in light of its small sample size, cross-sectional design and the complex psychosocial background of long-term inhalant users. CONCLUSION: White-matter abnormalities may underpin long-term behavioural and mental health problems seen in individuals with long-term inhalant use. |
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Authors:
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Murat Yücel; Andrew Zalesky; Michael J Takagi; Emre Bora; Alex Fornito; Michael Ditchfield; Gary F Egan; Christos Pantelis; Dan I Lubman |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of psychiatry & neuroscience : JPN Volume: 35 ISSN: 1488-2434 ISO Abbreviation: J Psychiatry Neurosci Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107859 Medline TA: J Psychiatry Neurosci Country: Canada |
Other Details:
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Languages: eng Pagination: 409-12 Citation Subset: IM |
Affiliation:
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Orygen Youth Health Research Centre, 35 Poplar Rd., Parkville, Victoria 3052, Australia. murat@unimelb.edu.au |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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