Document Detail


White matter abnormalities correlate with neurocognitive performance in patients with HBV-related cirrhosis.
MedLine Citation:
PMID:  22877508     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: White matter (WM) abnormalities are common in cirrhotic patients and possibly contribute to hepatic encephalopathy (HE), a frequent neuropsychiatric complication of cirrhosis. However, little is known about these WM abnormalities and their relationship to neurocognitive deficits in patients with HBV-related cirrhosis. METHODS: Three-dimensional T1-weighted magnetic resonance imaging and diffusion tensor imaging (DTI) scans were obtained from 67 patients with HBV-related cirrhosis and 40 controls. Voxel-based morphometry and voxel-based DTI were performed to detect macroscopic atrophy and damage to the microstructural integrity of the WM, respectively. Correlation analyses were performed to investigate the relationships between WM abnormalities and neurocognitive performances. RESULTS: Patients with cirrhosis exhibited significantly decreased WM volume and fractional anisotropy (FA) values, especially in the corpus callosum, thalamus, extra-nuclear area, sensorimotor area, fusiform gyrus, lingual gyrus, and frontal lobes. These abnormalities were more severe with increasing Child-Pugh stage, minimal HE, and previous overt HE. Changes in the corpus callosum, frontal lobe, sensorimotor area, internal capsule, and temporal-occipital lobes were correlated with poor neurocognitive performance. Also, the significantly decreased global WM volume and mean FA value were correlated with poor neurocognitive performances. CONCLUSIONS: Diffuse WM abnormalities are common in patients with HBV-related cirrhosis. Advanced liver disease and episodes of HE are two factors associated with WM abnormalities. The correlation between poor neurocognitive performance and WM abnormalities suggests that WM abnormalities may be one of mechanisms underlying neurocognitive deficits in patients with HBV-related cirrhosis.
Authors:
Hua-Jun Chen; Yu Wang; Xi-Qi Zhu; Ying Cui; Yu-Chen Chen; Gao-Jun Teng
Related Documents :
15785938 - Secondary renal fanconi syndrome caused by valproate therapy.
8886728 - Doppler-duplex ultrasound in renal colic.
21548758 - Role of hnrnp-a1 and mir-590-3p in neuronal death: genetics and expression analysis in ...
16443418 - Comparison of two hemofiltration protocols for prevention of contrast-induced nephropat...
21087228 - Interleukin-18 is elevated in the horny layer in patients with atopic dermatitis and is...
12793888 - Erythropoietin mimics the acute phase response in critical illness.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-6
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  -     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Sleep disturbances in 'migraine without aura' - A questionnaire based study.
Next Document:  Cognitive deficit is related to immune-cell beta-NGF in multiple sclerosis patients.