Document Detail

White clot syndrome.
MedLine Citation:
PMID:  3368814     Owner:  NLM     Status:  MEDLINE    
Heparin therapy is currently a vital component in the medical management of thromboembolic events. Despite its widespread use, it is associated with relatively few complications, and these are usually minor and quickly reversible. Recently a much more dramatic and serious complication of heparin therapy has been identified. In heparin-induced thrombocytopenia with associated thrombosis or "white clot syndrome," patients have paradoxic thromboembolic events while receiving heparin. These events are of acute onset and of major consequence, often resulting in limb loss or death. This paper describes our own experience with ten patients in whom the white clot syndrome occurred during heparin therapy for thrombotic or embolic events. Both porcine and bovine heparin preparations were being given through various routes. In the three cases in which platelet aggregation testing was completed, results were positive. Our ten patients ultimately had a 20% major limb amputation rate and an overall 50% mortality.
P E Stanton; J R Evans; A A Lefemine; N M Vo; G A Rannick; C V Morgan; P J Hinton; M Read
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  81     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-06-15     Completed Date:  1988-06-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  616-20     Citation Subset:  AIM; IM    
Department of Surgery, Quillen-Dishner College of Medicine, East Tennessee State University, Johnson City 37614.
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MeSH Terms
Heparin / adverse effects*
Middle Aged
Platelet Aggregation / drug effects
Platelet Count
Thrombocytopenia / blood,  chemically induced*,  diagnosis
Thrombosis / blood,  chemically induced*,  diagnosis
Reg. No./Substance:

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