Document Detail

White blood cells and bone marrow in typhoid fever.
MedLine Citation:
PMID:  3615066     Owner:  NLM     Status:  MEDLINE    
Leukopenia and/or neutropenia are thought to be characteristic findings in patients with typhoid fever. In a study of 29 children 8 months to 15 years of age mild neutropenia was found in 1 (3%) and leukopenia in 6 (20%) patients. These findings are similar to those reported recently. Epinephrine stimulation tests done in 3 patients excluded the possibility of excessive margination as a cause of neutropenia or leukopenia. In 3 neutropenic or leukopenic patients bone marrow examination showed hemophagocytosis with an increased number of histiocytes that had phagocytized neutrophils, red blood cells and platelets. This phenomenon was not seen in the bone marrow of 3 patients with normal white blood cell counts. Hemophagocytosis is an important mechanism in producing neutropenia, anemia and thrombocytopenia in several infectious and noninfectious disorders.
A A Mallouh; A R Sa'di
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  6     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-09-03     Completed Date:  1987-09-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  527-9     Citation Subset:  IM    
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MeSH Terms
Agranulocytosis / etiology*
Bone Marrow / pathology*
Child, Preschool
Epinephrine / diagnostic use
Leukocyte Count
Leukopenia / epidemiology,  etiology*
Neutropenia / epidemiology,  etiology*
Retrospective Studies
Typhoid Fever / blood*,  complications,  pathology
Reg. No./Substance:

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