| White blood cell and endothelial cell response to endovascular procedures in the leg. | |
| | |
MedLine Citation:
|
PMID: 15507888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM: The longterm patency of endovascular procedures is partly depending on restenosis by intimal hyperplasia, a process depending on inflammatory mechanisms resembling the mechanisms of normal repair and the process of atherosclerosis. The aim of this study was to characterize the inflammatory response of white blood cells (WBC) and endothelial cells following endovascular procedures in the leg. METHODS: Venous blood samples were drawn from a cubital vein before and 2 hours after intervention in 19 patients suffering from peripheral arterial occlusive disease (PAOD). Flow cytometry was used to identify and determine the concentrations of WBC and platelets and to measure CD11b/CD18 on WBC and CD41 on platelets. Soluble endothelial markers (sICAM-1, sE-selectin, sP-selectin and sVCAM-1) were measured by ELISA technique. RESULTS: WBC were downregulated following endovascular procedures. The endothelial cell response was limited and only downregulation of sP-selectin reached significant levels. The results were more evident in the group of patients with critical limb ischemia (CLI) compared to patients with intermittent claudication (IC). CONCLUSION: Endovascular procedures in the leg evoke only a limited response which is depending on the degree of ischemia and the magnitude of the interventional procedure. |
| | |
Authors:
|
P Danielsson; G Danielsson; L Truedsson; L Norgren |
Related Documents
:
|
8420328 - Induction of endothelial cell tissue factor activity by sera from patients with antipho... 18509248 - Endothelial function in patients with proteinuric primary glomerulonephritis. 15507518 - Effects of changes in body weight and insulin resistance on inflammation and endothelia... 19922018 - Effect of etanercept on serum levels of soluble cell adhesion molecules (sicam-1, svcam... 9292518 - Influence of interleukin-3 and other growth factors on alpha4beta1 integrin-mediated ad... 11721968 - Novel synthesized trimannose conjugate induces endocytosis and expression of immunostim... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: International angiology : a journal of the International Union of Angiology Volume: 23 ISSN: 0392-9590 ISO Abbreviation: Int Angiol Publication Date: 2004 Jun |
Date Detail:
|
Created Date: 2004-10-27 Completed Date: 2005-02-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8402693 Medline TA: Int Angiol Country: Italy |
Other Details:
|
Languages: eng Pagination: 122-7 Citation Subset: IM |
Affiliation:
|
Department of Vascular Diseases, University Hospital MAS, Malmö, Sweden. peter.danielsson@skane.se |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Antigens, CD11b / blood Antigens, CD18 / blood Down-Regulation E-Selectin / blood Endothelial Cells / physiology* Flow Cytometry Humans Intercellular Adhesion Molecule-1 / blood Intermittent Claudication / physiopathology*, therapy* Ischemia / physiopathology*, therapy* Leg / blood supply* Leukocytes / physiology* Middle Aged P-Selectin / physiology Vascular Cell Adhesion Molecule-1 / blood |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD11b; 0/Antigens, CD18; 0/E-Selectin; 0/P-Selectin; 0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reproducibility of proximal and distal transcutaneous oxygen pressure measurements during exercise i...
Next Document: Elevated soluble cell adhesion molecules E-selectin and intercellular cell adhesion molecule-1 in ty...