Document Detail


White blood cell and endothelial cell response to endovascular procedures in the leg.
MedLine Citation:
PMID:  15507888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: The longterm patency of endovascular procedures is partly depending on restenosis by intimal hyperplasia, a process depending on inflammatory mechanisms resembling the mechanisms of normal repair and the process of atherosclerosis. The aim of this study was to characterize the inflammatory response of white blood cells (WBC) and endothelial cells following endovascular procedures in the leg. METHODS: Venous blood samples were drawn from a cubital vein before and 2 hours after intervention in 19 patients suffering from peripheral arterial occlusive disease (PAOD). Flow cytometry was used to identify and determine the concentrations of WBC and platelets and to measure CD11b/CD18 on WBC and CD41 on platelets. Soluble endothelial markers (sICAM-1, sE-selectin, sP-selectin and sVCAM-1) were measured by ELISA technique. RESULTS: WBC were downregulated following endovascular procedures. The endothelial cell response was limited and only downregulation of sP-selectin reached significant levels. The results were more evident in the group of patients with critical limb ischemia (CLI) compared to patients with intermittent claudication (IC). CONCLUSION: Endovascular procedures in the leg evoke only a limited response which is depending on the degree of ischemia and the magnitude of the interventional procedure.
Authors:
P Danielsson; G Danielsson; L Truedsson; L Norgren
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International angiology : a journal of the International Union of Angiology     Volume:  23     ISSN:  0392-9590     ISO Abbreviation:  Int Angiol     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-10-27     Completed Date:  2005-02-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8402693     Medline TA:  Int Angiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  122-7     Citation Subset:  IM    
Affiliation:
Department of Vascular Diseases, University Hospital MAS, Malmö, Sweden. peter.danielsson@skane.se
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Antigens, CD11b / blood
Antigens, CD18 / blood
Down-Regulation
E-Selectin / blood
Endothelial Cells / physiology*
Flow Cytometry
Humans
Intercellular Adhesion Molecule-1 / blood
Intermittent Claudication / physiopathology*,  therapy*
Ischemia / physiopathology*,  therapy*
Leg / blood supply*
Leukocytes / physiology*
Middle Aged
P-Selectin / physiology
Vascular Cell Adhesion Molecule-1 / blood
Chemical
Reg. No./Substance:
0/Antigens, CD11b; 0/Antigens, CD18; 0/E-Selectin; 0/P-Selectin; 0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1

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