| White blood cell count and the sodium to potassium ratio to screen for hypoadrenocorticism in dogs. | |
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MedLine Citation:
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PMID: 22092627 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Abnormal sodium to potassium (Na : K) ratios can raise suspicion for hypoadrenocorticism (HA). Although dogs with HA usually have normal leukograms, their white blood cell counts may be useful in screening for HA. OBJECTIVES: To examine the utility of combining the Na : K ratio with white blood cell counts to screen for HA in hospitalized dogs requiring fluid treatment administered IV. ANIMALS: Fifty-three dogs with confirmed HA and 110 sick dogs confirmed not to have HA. METHODS: Retrospective, case-control study. Dogs were included if they were hospitalized and administered fluids IV, had a complete blood count and measurement of serum Na and K concentrations. HA was diagnosed using an ACTH stimulation test, or ruled out by measurement of basal serum cortisol concentration. RESULTS: The receiver operating characteristic (ROC) curve for the lymphocyte count was not significantly different from the ROC curve of the Na : K ratio (P = .55). The ROC curve for the model combining the Na : K ratio and lymphocyte count was superior for identifying dogs with HA compared to the Na : K ratio (P = .02) or lymphocyte count (P = .005) alone. At the 100% sensitivity cutoff, lymphocyte count was more specific for detection of HA than Na : K (P < .001). CONCLUSIONS AND CLINICAL IMPORTANCE: A combination of the Na : K ratio and lymphocyte count provides a better screening test for HA compared to the Na : K ratio or lymphocyte count alone. At 100% sensitivity, the lymphocyte count is a more specific test for HA than the Na : K. |
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Authors:
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M Seth; K J Drobatz; D B Church; R S Hess |
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Publication Detail:
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Type: Journal Article Date: 2011-11-01 |
Journal Detail:
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Title: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine Volume: 25 ISSN: 1939-1676 ISO Abbreviation: J. Vet. Intern. Med. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708660 Medline TA: J Vet Intern Med Country: United States |
Other Details:
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Languages: eng Pagination: 1351-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 by the American College of Veterinary Internal Medicine. |
Affiliation:
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Department of Clinical Sciences, Matthew J. Ryan Veterinary Hospital of The University of Pennsylvania, Philadelphia, PA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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