Document Detail

White blood cell count and haematocrit as predictors of coronary recurrence after myocardial infarction.
MedLine Citation:
PMID:  4089799     Owner:  NLM     Status:  MEDLINE    
Baseline white blood cell count (WCC) and haematocrit were examined in relation to recurrent coronary events and to all-cause mortality in 2026 persons enrolled in the first Persantin-Aspirin Reinfarction Study (PARIS-1) 2-60 months after myocardial infarction. WCC was strongly related to coronary recurrence (relative risk 3.5 for men with WCC greater than or equal to 9 X 10(9)/l vs men with WCC less than 5 X 10(9)/l) and total mortality (relative risk 2.6). No such relationships were found for haematocrit. WCC correlated also with cigarette-smoking, diuretic use, serum cholesterol and uric acid; however, the associations with coronary recurrence and total mortality persisted on multiple linear and logistic regression analysis including these variables and treatment group (p less than 0.001). WCC is therefore an easily-measured prognostic variable in survivors of myocardial infarction. Furthermore, we suggest that white blood cells may promote myocardial ischaemia by capillary plugging and/or release of toxic oxygen metabolites.
G D Lowe; S G Machado; W F Krol; B A Barton; C D Forbes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  54     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1986-02-26     Completed Date:  1986-02-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  700-3     Citation Subset:  IM    
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MeSH Terms
Aspirin / pharmacology
Cholesterol / blood
Coronary Disease / blood*
Dipyridamole / pharmacology
Diuretics / therapeutic use
Leukocyte Count
Middle Aged
Myocardial Infarction / blood*
Sex Factors
Uric Acid / blood
Reg. No./Substance:
0/Diuretics; 50-78-2/Aspirin; 57-88-5/Cholesterol; 58-32-2/Dipyridamole; 69-93-2/Uric Acid

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