Document Detail

White blood cell consumption in the microcirculation after a major burn.
MedLine Citation:
PMID:  762735     Owner:  NLM     Status:  MEDLINE    
The mesenteric microvasculature was observed before and after a distant full-thickness cutaneous burn in rats. Diameters, flow velocities, and white blood cell sticking and emigration were measured. Between 30 and 360 minutes postburn 13 to 16 WBC's were found to stick to the venular walls which had an area of 1.57 x 10(4) microns(2). Therefore, the number of WBC's emigrating from the vascular compartment during the 6-hour observation period could be as many as 0.51 X 10(9)/kg. Based on known values for total stores of WBC's, the data suggest that granulocyte sticking and emigration could account for a consumption of granulocytes that on an acute basis could deplete the body stores, which could explain the apparent decrease in total body granulocytes seen clinically following major thermal trauma.
E Eriksson; R C Straube; M C Robson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of trauma     Volume:  19     ISSN:  0022-5282     ISO Abbreviation:  J Trauma     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-04-25     Completed Date:  1979-04-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  94-7     Citation Subset:  AIM; IM    
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MeSH Terms
Burns / blood*
Leukocyte Count*
Microcirculation* / ultrastructure

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