| White adipose tissue genome wide-expression profiling and adipocyte metabolic functions after soy protein consumption in rats. | |
| | |
MedLine Citation:
|
PMID: 20471815 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Obesity is associated with an increase in adipose tissue mass due to an imbalance between high dietary energy intake and low physical activity; however, the type of dietary protein may contribute to its development. The aim of the present work was to study the effect of soy protein versus casein on white adipose tissue genome profiling, and the metabolic functions of adipocytes in rats with diet-induced obesity. The results showed that rats fed a Soy Protein High-Fat (Soy HF) diet gained less weight and had lower serum leptin concentration than rats fed a Casein High-Fat (Cas HF) diet, despite similar energy intake. Histological studies indicated that rats fed the Soy HF diet had significantly smaller adipocytes than those fed the Cas HF diet, and this was associated with a lower triglyceride/DNA content. Fatty acid synthesis in isolated adipocytes was reduced by the amount of fat consumed but not by the type of protein ingested. Expression of genes of fatty acid oxidation increased in adipose tissue of rats fed Soy diets; microarray analysis revealed that Soy protein consumption modified the expression of 90 genes involved in metabolic functions and inflammatory response in adipose tissue. Network analysis showed that the expression of leptin was regulated by the type of dietary protein and it was identified as a central regulator of the expression of lipid metabolism genes in adipose tissue. Thus, soy maintains the size and metabolic functions of adipose tissue through biochemical adaptations, adipokine secretion, and global changes in gene expression. |
| | |
Authors:
|
Maria E Frigolet; Nimbe Torres; Laura Uribe-Figueroa; Claudia Rangel; Gerardo Jimenez-Sanchez; Armando R Tovar |
Related Documents
:
|
15971155 - Soy protein influences insulin sensitivity and cardiovascular risk in male lean shhf rats. 11273945 - Soy-containing diet suppresses chronic neuropathic sensory disorders in rats. 11850125 - Dietary genistein down-regulates androgen and estrogen receptor expression in the rat p... 7549805 - A simplified method to quantify isoflavones in commercial soybean diets and human urine... 22564595 - Quantification of macrovesicular and microvesicular hepatic steatosis in rats using 3.0... 17430935 - Performance and ruminal fermentation of dairy cows fed whole cottonseed with elevated c... |
Publication Detail:
|
Type: Journal Article Date: 2010-05-14 |
Journal Detail:
|
Title: The Journal of nutritional biochemistry Volume: 22 ISSN: 1873-4847 ISO Abbreviation: J. Nutr. Biochem. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9010081 Medline TA: J Nutr Biochem Country: United States |
Other Details:
|
Languages: eng Pagination: 118-29 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Departamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, DF 14000, México; Posgrado en Ciencias Bioquímicas, Facultad de Química, UNAM, DF 04510, México. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dietary catechins and procyanidins modulate zinc homeostasis in human HepG2 cells.
Next Document: Promoter analysis of the human ascorbic acid transporters SVCT1 and 2: mechanisms of adaptive regula...