Document Detail


White matter microstructural integrity and executive function in Parkinson's disease.
MedLine Citation:
PMID:  23321049     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent studies suggest that white matter abnormalities contribute to both motor and non-motor symptoms of Parkinson’s disease. The present study was designed to investigate the degree to which diffusion tensor magnetic resonance imaging (DTI) indices are related to executive function in Parkinson’s patients. We used tract-based spatial statistics to compare DTI data from 15 patients to 15 healthy, age- and education-matched controls. We then extracted mean values of fractional anisotropy (FA) and mean diffusivity (MD) within an a priori frontal mask. Executive function composite Z scores were regressed against these DTI indices, age, and total intracranial volume. In Parkinson’s patients, FA was related to executive composite scores, and both indices were related to Stroop interference scores. We conclude that white matter microstructural abnormalities contribute to cognitive deficits in Parkinson’s disease. Further work is needed to determine whether these white matter changes reflect the pathological process or a clinically important comorbidity.
Authors:
Catherine Gallagher; Brian Bell; Barbara Bendlin; Matthew Palotti; Ozioma Okonkwo; Aparna Sodhi; Rachel Wong; Laura Buyan-Dent; Sterling Johnson; Auriel Willette; Auriel Wilette; Sandra Harding; Nancy Ninman; Erik Kastman; Andrew Alexander
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2013-01-15
Journal Detail:
Title:  Journal of the International Neuropsychological Society : JINS     Volume:  19     ISSN:  1469-7661     ISO Abbreviation:  J Int Neuropsychol Soc     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-19     Completed Date:  2013-11-19     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  9503760     Medline TA:  J Int Neuropsychol Soc     Country:  England    
Other Details:
Languages:  eng     Pagination:  349-54     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Anisotropy
Brain / pathology*
Case-Control Studies
Cognition Disorders / etiology*
Diffusion Magnetic Resonance Imaging
Executive Function / physiology*
Female
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Nerve Fibers, Myelinated / pathology*
Neuropsychological Tests
Parkinson Disease / complications*,  pathology*
Grant Support
ID/Acronym/Agency:
1UL1RR025011/RR/NCRR NIH HHS; UL1 RR025011/RR/NCRR NIH HHS; UL1 TR000427/TR/NCATS NIH HHS
Comments/Corrections
Erratum In:
J Int Neuropsychol Soc. 2013 Apr;19(4):492
Note: Wilette, Auriel [corrected to Willette, Auriel]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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