Document Detail

White Matter Lesions Progression in Migraine with Aura: A Clinical and MRI Longitudinal Study.
MedLine Citation:
PMID:  22268442     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To prospectively evaluate longitudinal changes in white matter lesions (WMLs) in migraineurs with aura, by magnetic resonance imaging (MRI), and to correlate WMLs modifications with patients' clinical characteristics. METHODS: Forty-one consecutive migraineurs with aura were followed for a mean time of 33.2 months. Patients underwent MRI at baseline and follow-up and were evaluated for cerebrovascular risk factors. Presence of WMLs on MRI was assessed by two neuroradiologists. RESULTS: WMLs were present in 26 subjects (63.4%) at baseline MRI. At follow-up a total of 8 patients had new WMLs (19.5%). There was a significant correlation between aura duration and number of new WMLs, and between the number of migraine attacks with aura and new WMLs. CONCLUSIONS: Our study demonstrates that in migraine with aura WMLs number can progress over time and suggests an association between aura features and WMLs progression. Studies with a higher number of patients are required to confirm these findings. J Neuroimaging 2012;XX:1-6.
Lavinia Dinia; Laura Bonzano; Beatrice Albano; Cinzia Finocchi; Massimo Del Sette; Laura Saitta; Lucio Castellan; Carlo Gandolfo; Luca Roccatagliata
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-23
Journal Detail:
Title:  Journal of neuroimaging : official journal of the American Society of Neuroimaging     Volume:  -     ISSN:  1552-6569     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102705     Medline TA:  J Neuroimaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 by the American Society of Neuroimaging.
From the Department of Neurosciences, Ophthalmology, and Genetics, University of Genoa, Genoa, Italy (LD, LB, BA, CF, MDS, CG, LR); Magnetic Resonance Research Centre on Nervous System Diseases, University of Genoa, Genoa, Italy (LB, LS, LC, LR); Neurology Unit, Sant'Andrea Hospital, La Spezia, Italy (MDS); and Department of Neuroradiology, San Martino Hospital, Genoa, Italy (LS, LC).
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