| White matter hyperintensity penumbra. | |
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MedLine Citation:
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PMID: 21636811 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: White matter hyperintensities (WMHs) are associated with progressive age-related cognitive decline and cardiovascular risk factors, but their biological relevance as indicators of generalized white matter injury is unclear. Diffusion tensor imaging provides more sensitive indications of subtle white matter disruption and can therefore clarify whether WMHs represent foci of generalized white matter damage that extends over a broader neighborhood. METHODS: Two hundred eight participants from the University of California, Davis Alzheimer's Disease Center received a comprehensive clinical evaluation and brain MRI including fluid-attenuated inversion recovery and diffusion tensor imaging sequences. Voxelwise maps of WMHs were produced from fluid-attenuated inversion recovery using a standardized WMH detection protocol. Fractional anisotropy maps were calculated from diffusion tensor imaging. All WMH and fractional anisotropy maps were coregistered to a standardized space. For each normal-appearing white matter voxel in each subject fluid-attenuated inversion recovery scan, a neighborhood white matter injury score was calculated that increased with increasing number and proximity of WMH in the vicinity of the normal-appearing white matter voxel. Fractional anisotropy was related to neighborhood white matter injury using a nonlinear mixed effect model controlling for relevant confounding factors. RESULTS: Fractional anisotropy was found to decrease as neighborhood white matter injury increased (β = -0.0017/%, P < 0.0001) with an accelerated rate (P < 0.0001) for neighborhood white matter injury >0.4. An increase of 1% in neighborhood white matter injury score was associated with a decrease in mean fractional anisotropy of 0.012 (P < 0.001). CONCLUSIONS: WMH may represent foci of more widespread and subtle white matter changes rather than distinct, sharply delineated anatomic abnormalities. We use the term white matter hyperintensities penumbra to explain this phenomenon. |
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Authors:
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Pauline Maillard; Evan Fletcher; Danielle Harvey; Owen Carmichael; Bruce Reed; Dan Mungas; Charles DeCarli |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-06-02 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 42 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-28 Completed Date: 2011-09-09 Revised Date: 2012-05-17 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 1917-22 Citation Subset: IM |
Affiliation:
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Department of Neurology and Center for Neuroscience, School of Medicine, University of California, Davis, Davis, CA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anisotropy Brain / pathology* Cardiology Cardiovascular Diseases / diagnosis Case-Control Studies Cognition Disorders / pathology Diffusion Tensor Imaging / methods Female Humans Leukoencephalopathies / pathology* Magnetic Resonance Imaging / methods Male Middle Aged Risk |
| Grant Support | |
ID/Acronym/Agency:
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K01 AG030514/AG/NIA NIH HHS; K01 AG030514/AG/NIA NIH HHS; K01 AG030514-04/AG/NIA NIH HHS; P30 AG010129/AG/NIA NIH HHS; R01 AG 031563/AG/NIA NIH HHS; R01 AG010220/AG/NIA NIH HHS; R01 AG021028/AG/NIA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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