Document Detail

White matter hyperintensity burden and susceptibility to cerebral ischemia.
MedLine Citation:
PMID:  20947843     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: White matter hyperintensity (WMH) burden increases risk of ischemic stroke; furthermore, it predicts infarct growth in acute cerebral ischemia. We hypothesized that WMH would be less severe in patients with TIA as compared to those with acute ischemic stroke and completed infarct.
METHODS: Cases (TIA, n = 30) and controls (acute ischemic stroke, n = 120) were selected from an ongoing longitudinal cohort study of patients with stroke and matched for age, gender, and race/ethnicity. All subjects had brain MRI within 48 hours of presentation to evaluate for evidence of acute cerebral ischemia. WMH burden on MRI was quantified using a validated computer-assisted program with high inter-rater reliability.
RESULTS: Median WMH volume in individuals with TIA was 3.7 cm³ (interquartile range, 1.5 - 8.33 cm³) compared to 6.9 cm³ (interquartile range, 3.1-11.9 cm³) in acute ischemic stroke (P < 0.04). In multivariable analysis, the odds of completed infarct were higher (OR, 2.19; 95% CI, 1.27-3.77; P < 0.005) in subjects with larger volumes of WMH.
CONCLUSIONS: WMH burden was significantly less in subjects with TIA as opposed to those with ischemic stroke. These data provide further evidence to support a detrimental role of WMH burden on the capacity of cerebral tissue to survive acute ischemia.
Natalia S Rost; Kaitlin Fitzpatrick; Alessandro Biffi; Allison Kanakis; William Devan; Christopher D Anderson; Lynelle Cortellini; Karen L Furie; Jonathan Rosand
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-10-14
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  41     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-30     Completed Date:  2010-12-22     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2807-11     Citation Subset:  IM    
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MeSH Terms
Age Factors
Brain / pathology*
Brain Ischemia / epidemiology*,  pathology*
Case-Control Studies
Cerebral Infarction / epidemiology,  pathology
Cohort Studies
Ethnic Groups
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
Hyperlipidemias / complications,  drug therapy,  epidemiology
Image Processing, Computer-Assisted
Ischemic Attack, Transient / epidemiology,  pathology
Longitudinal Studies
Magnetic Resonance Imaging
Middle Aged
Sex Factors
Stroke / epidemiology,  pathology
Grant Support
5P50NS051343/NS/NINDS NIH HHS; 5P50NS051343-04/NS/NINDS NIH HHS; 5R01NS059727/NS/NINDS NIH HHS; K23 NS064052/NS/NINDS NIH HHS; K23 NS064052-01A1/NS/NINDS NIH HHS; K23 NS064052-02/NS/NINDS NIH HHS; K23 NS064052-03/NS/NINDS NIH HHS; K23NS064052-01A/NS/NINDS NIH HHS; R01 NS063925/NS/NINDS NIH HHS; R01NS063925/NS/NINDS NIH HHS
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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