Document Detail

White Matter Abnormalities Are Related to Microstructural Changes in Preterm Neonates at Term-Equivalent Age: A Diffusion Tensor Imaging and Probabilistic Tractography Study.
MedLine Citation:
PMID:  22241389     Owner:  NLM     Status:  Publisher    
BACKGROUND AND PURPOSE:Preterm infants have a high risk of brain injury and neurodevelopmental impairment, often associated with WMA on conventional MR imaging. DTI can provide insight into white matter microstructure. The aim of this study was to investigate the association between WMA on conventional MR imaging and DTI parameters in specific fibers in preterm neonates at term-equivalent age.MATERIALS AND METHODS:Seventy preterm neonates (39 boys and 31 girls) were included in the study. WMA were classified as no, mild, moderate, or severe. Probabilistic tractography provided tract volumes, FA, MD, λ(//), and λ(⊥) in the CST, SLF, TRs, and corpus callosum. Data were compared by using MANOVA, and adjustment for multiple comparisons was performed.RESULTS:Important associations were found between WMA and microstructural changes. Compared with neonates with no WMA (n = 41), those with mild WMA (n = 27) had significantly increased λ(⊥) and MD in the left ATR, the left sensory STR, the bilateral motor STR, and for λ(⊥) also in the right CST; FA decreased significantly in the left sensory STR. Diminished tract volumes and altered diffusion indices were also observed in the 2 neonates with moderate WMA.CONCLUSIONS:Altered DTI indices in specific tracts, with λ(⊥) as most prominent, are associated with mild WMA in preterm neonates at term-equivalent age.
Y Liu; A Aeby; D Balériaux; P David; J Absil; V De Maertelaer; P Van Bogaert; F Avni; T Metens
Related Documents :
2991489 - Rotavirus antibodies in the mother and her breast-fed infant.
11693679 - Effects of retention intervals on the magnitude of optokinetic rotation-induced taste a...
4041499 - Nonmigrating rhythmic activity in the stomach and duodenum of neonates.
2011419 - Human breast milk contains bovine igg. relationship to infant colic?
3735009 - Comparison of macronutrient concentration of preterm human milk between two milk expres...
19774349 - Zinc and copper concentrations in human preterm milk.
18363629 - Ventilatory strategies for the extremely premature infant.
21039209 - Birth weight discordance of twin pairs and their subsequent growth patterns.
1126099 - The magnesium load test: ii. correlation of clinical and laboratory data in neonates.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-12
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  -     ISSN:  1936-959X     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Departments of Radiology and Pediatric Neurology, and Laboratoire de Cartographie Fonctionnelle du Cerveau, ULB-Hôpital Erasme, Brussels, Belgium; and Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire and Department of Biostatistics and Medical Informatics, ULB, Brussels, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Dual-Energy CT in the Evaluation of Intracerebral Hemorrhage of Unknown Origin: Differentiation betw...
Next Document:  Acute effects of alcohol on the human brain: diffusion tensor imaging study.