Document Detail


White Matter Abnormalities Are Related to Microstructural Changes in Preterm Neonates at Term-Equivalent Age: A Diffusion Tensor Imaging and Probabilistic Tractography Study.
MedLine Citation:
PMID:  22241389     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE:Preterm infants have a high risk of brain injury and neurodevelopmental impairment, often associated with WMA on conventional MR imaging. DTI can provide insight into white matter microstructure. The aim of this study was to investigate the association between WMA on conventional MR imaging and DTI parameters in specific fibers in preterm neonates at term-equivalent age.MATERIALS AND METHODS:Seventy preterm neonates (39 boys and 31 girls) were included in the study. WMA were classified as no, mild, moderate, or severe. Probabilistic tractography provided tract volumes, FA, MD, λ(//), and λ(⊥) in the CST, SLF, TRs, and corpus callosum. Data were compared by using MANOVA, and adjustment for multiple comparisons was performed.RESULTS:Important associations were found between WMA and microstructural changes. Compared with neonates with no WMA (n = 41), those with mild WMA (n = 27) had significantly increased λ(⊥) and MD in the left ATR, the left sensory STR, the bilateral motor STR, and for λ(⊥) also in the right CST; FA decreased significantly in the left sensory STR. Diminished tract volumes and altered diffusion indices were also observed in the 2 neonates with moderate WMA.CONCLUSIONS:Altered DTI indices in specific tracts, with λ(⊥) as most prominent, are associated with mild WMA in preterm neonates at term-equivalent age.
Authors:
Y Liu; A Aeby; D Balériaux; P David; J Absil; V De Maertelaer; P Van Bogaert; F Avni; T Metens
Related Documents :
2250639 - Breastfeeding the low-birthweight infant.
21885159 - Severe cutaneous aspergillosis in a premature neonate linked to nonsterile disposable g...
8917959 - The weaning diet and dental health.
2011419 - Human breast milk contains bovine igg. relationship to infant colic?
16970569 - Transfer of the antidepressant mirtazapine into breast milk.
16871349 - Fractional sodium excretion, urinary osmolality and specific gravity in preterm infants...
24809789 - Increased recombinant activated factor vii use and need for surgical reexploration foll...
7936779 - Cardiopulmonary resuscitation of the newborn. an update.
2366719 - Temporary banding of the gastroesophageal juncture in a very small neonate with esophag...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-12
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  -     ISSN:  1936-959X     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Departments of Radiology and Pediatric Neurology, and Laboratoire de Cartographie Fonctionnelle du Cerveau, ULB-Hôpital Erasme, Brussels, Belgium; and Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire and Department of Biostatistics and Medical Informatics, ULB, Brussels, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Dual-Energy CT in the Evaluation of Intracerebral Hemorrhage of Unknown Origin: Differentiation betw...
Next Document:  Acute effects of alcohol on the human brain: diffusion tensor imaging study.