Document Detail

Which target for DBS in Parkinson's disease? Subthalamic nucleus versus globus pallidus internus.
MedLine Citation:
PMID:  11487215     Owner:  NLM     Status:  MEDLINE    
We selected 14 patients with advanced idiopathic Parkinson's disease (PD) and examined the clinical effects of STN DBS versus GPi DBS. Nine patients underwent bilateral STN DBS and five underwent bilateral GPi patients. All patients were followed for at least 12 months. The evaluation was performed on and off drug before surgery; on-drug/on-DBS and off-drug/on-DBS at 1, 3, 6 and 12 months after stereotactic surgery. At 1 and 3 months after surgery in off-drug/on-DBS condition, both groups showed an improvement in motor score (UPDRS III). Nevertheless, the results changed after long-term stimulation in the two groups. Chronic STN DBS is superior to GPi DBS in the amelioration of the clinical features and in the decrease of time spent in the off state. The efficacy in reduction of LID was comparable at 1 and 3 months after surgery, but the results were better in STN DBS after chronic stimulation. The L-dopa dose was reduced only in the STN group.
A E Scotto di Luzio; F Ammannati; P Marini; S Sorbi; P Mennonna
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology     Volume:  22     ISSN:  1590-1874     ISO Abbreviation:  Neurol. Sci.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-08-06     Completed Date:  2001-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100959175     Medline TA:  Neurol Sci     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  87-8     Citation Subset:  IM    
Neurological Clinic I, University School of Medicine, Careggi, Florence, Italy.
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MeSH Terms
Electric Stimulation Therapy*
Electrodes, Implanted
Follow-Up Studies
Globus Pallidus / physiopathology*
Levodopa / therapeutic use
Middle Aged
Parkinson Disease / physiopathology,  therapy*
Recovery of Function / physiology
Subthalamic Nucleus / physiopathology*
Treatment Outcome
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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