Document Detail

Which route of misoprostol application is more advantageous prior to fractional curettage in postmenopausal patients?
MedLine Citation:
PMID:  18773214     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine the effectiveness and potential side effects of oral, vaginal, and sublingual intake of misoprostol on cervical dilatation prior to fractional curettage in patients with postmenopausal bleeding. METHODS: Seventy-six patients with postmenopausal bleeding during a period of 18 months were included in this randomized controlled trial. Patients were given 400 microg of misoprostol through the vaginal, oral, and sublingual routes, 12 h prior to the fractional curettage procedure. The degree of cervical dilatation, duration of the procedure, the side effects and complications were noted. RESULTS: When compared with the control group, misoprostol administered orally or sublingually was found to have a significant effect on cervical dilatation (P < 0.05). Of the three groups, nausea was found to be more common in the orally administered misoprostol group. CONCLUSIONS: We conclude that the oral or sublingual application of misoprostol prior to fractional curettage in patients with postmenopausal bleeding decreases the need for cervical dilatation.
Muge Temel; Fikret Gokhan Goynumer; Lale Wetherilt; Birol Durukan
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2008-09-05
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  279     ISSN:  1432-0711     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-03-26     Completed Date:  2009-06-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  637-42     Citation Subset:  IM    
Obstetrics and Gynecology Department, Istanbul Goztepe Education and Research Hospital, Goztepe, Istanbul, Turkey.
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MeSH Terms
Administration, Intravaginal
Administration, Sublingual
Dilatation and Curettage*
Drug Administration Routes
Middle Aged
Misoprostol / administration & dosage*
Oxytocics / administration & dosage*
Preoperative Care / methods*
Reg. No./Substance:
0/Oxytocics; 59122-46-2/Misoprostol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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