Document Detail

Which phototherapy system is most effective in lowering serum bilirubin in very preterm infants?
MedLine Citation:
PMID:  16491004     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the effectiveness of various phototherapy systems in lowering serum bilirubin levels in preterm infants. METHODS: This randomized clinical trial enrolled 140 preterm infants with gestational age < or =30 weeks and presenting nonhemolytic hyperbilirubinemia. When total serum bilirubin level reached 6.0 mg/dl (102.6 micromol/l), eligible infants were randomly assigned to four study groups: conventional, fiberoptic Wallaby, fiberoptic Biliblanket, and combined phototherapy. Efficacy was assessed by comparing highest serum bilirubin levels, duration of treatment, and number of infants requiring exchange transfusion. RESULTS: Our results confirm that fiberoptic phototherapy, both Wallaby and Biliblanket, had the same effectiveness of conventional phototherapy. The best results have been obtained using combined phototherapy, which allowed to reach lower serum bilirubin levels, a shorter duration of treatment and a significant reduction of exchange transfusions. CONCLUSION: Our data suggest that combined phototherapy should be the method of choice in treating hyperbilirubinemia in very preterm infants.
Costantino Romagnoli; Enrico Zecca; Patrizia Papacci; Giovanni Vento; Pietro Girlando; Caterina Latella
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  21     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2006  
Date Detail:
Created Date:  2006-02-21     Completed Date:  2006-06-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  204-9     Citation Subset:  IM    
Copyright Information:
(c) 2006 S. Karger AG, Basel
Division of Neonatology, Catholic University of Rome, Rome, Italy.
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MeSH Terms
Bilirubin / blood*
Hyperbilirubinemia, Neonatal / therapy*
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / therapy*
Infant, Very Low Birth Weight
Phototherapy / instrumentation*,  methods
Time Factors
Reg. No./Substance:

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