| Which phototherapy system is most effective in lowering serum bilirubin in very preterm infants? | |
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MedLine Citation:
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PMID: 16491004 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the effectiveness of various phototherapy systems in lowering serum bilirubin levels in preterm infants. METHODS: This randomized clinical trial enrolled 140 preterm infants with gestational age < or =30 weeks and presenting nonhemolytic hyperbilirubinemia. When total serum bilirubin level reached 6.0 mg/dl (102.6 micromol/l), eligible infants were randomly assigned to four study groups: conventional, fiberoptic Wallaby, fiberoptic Biliblanket, and combined phototherapy. Efficacy was assessed by comparing highest serum bilirubin levels, duration of treatment, and number of infants requiring exchange transfusion. RESULTS: Our results confirm that fiberoptic phototherapy, both Wallaby and Biliblanket, had the same effectiveness of conventional phototherapy. The best results have been obtained using combined phototherapy, which allowed to reach lower serum bilirubin levels, a shorter duration of treatment and a significant reduction of exchange transfusions. CONCLUSION: Our data suggest that combined phototherapy should be the method of choice in treating hyperbilirubinemia in very preterm infants. |
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Authors:
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Costantino Romagnoli; Enrico Zecca; Patrizia Papacci; Giovanni Vento; Pietro Girlando; Caterina Latella |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Fetal diagnosis and therapy Volume: 21 ISSN: 1015-3837 ISO Abbreviation: Fetal. Diagn. Ther. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-02-21 Completed Date: 2006-06-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107463 Medline TA: Fetal Diagn Ther Country: Switzerland |
Other Details:
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Languages: eng Pagination: 204-9 Citation Subset: IM |
Copyright Information:
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(c) 2006 S. Karger AG, Basel |
Affiliation:
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Division of Neonatology, Catholic University of Rome, Rome, Italy. cromagnoli@rm.unicatt.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bilirubin
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blood* Female Humans Hyperbilirubinemia, Neonatal / therapy* Infant, Low Birth Weight Infant, Newborn Infant, Premature Infant, Premature, Diseases / therapy* Infant, Very Low Birth Weight Male Phototherapy / instrumentation*, methods Time Factors |
| Chemical | |
Reg. No./Substance:
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635-65-4/Bilirubin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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