| Which lumen is the source of catheter-related bloodstream infection in patients with multi-lumen central venous catheters? | |
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MedLine Citation:
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PMID: 23274928 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: Paired blood cultures, drawn from the catheter and a peripheral vein, used for calculation of the differential time to positivity (DTP), have been proposed for the detection of catheter-related bloodstream infections (CRBSIs). The most relevant catheter lumen to be sampled in multi-lumen central venous catheters (CVCs) has not been recommended. METHODS: Forty-four febrile neutropaenic patients, following haematopoietic stem cell transplantation (HSCT) and with multi-lumen CVCs in place, were investigated using the DTP method of blood samples drawn from every lumen of the CVC and a peripheral vein. RESULTS: Twelve of 44 patients (27 %) had CRBSIs, as determined by the DTP method. In 10 of 12 (83 %) febrile neutropaenic patients, after HSCT, CRBSIs originated from the CVC lumen used for parenteral nutrition and blood products only. 17 % had CRBSI originating from the other CVC lumen (p = 0.039). CONCLUSION: In most patients, CRBSIs originated from the CVC lumen used for parenteral nutrition and blood products, indicating that this lumen is the main source of CRBSI. However, since 17 % of patients had CRBSIs originating from another lumen, each lumen of multi-lumen CVCs has to be considered as a potential source of CRBSI and should, ideally, be sampled in order to avoid failure in diagnostic procedures. |
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Authors:
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R Krause; T Valentin; H Salzer; M Hönigl; A Valentin; H Auner; I Zollner-Schwetz |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-29 |
Journal Detail:
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Title: Infection Volume: - ISSN: 1439-0973 ISO Abbreviation: Infection Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0365307 Medline TA: Infection Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Section of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 20, 8036, Graz, Austria, robert.krause@medunigraz.at. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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