Document Detail


Which imaging modality is superior for prediction of response to neoadjuvant chemotherapy in patients with triple negative breast cancer?
MedLine Citation:
PMID:  23476649     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Background and Objectives. Triple negative breast cancer (TNBC) has been shown to be generally chemosensitive. We sought to investigate the utility of mammography (MMG), ultrasonography (US), and breast magnetic resonance imaging (MRI) in predicting residual disease following neoadjuvant chemotherapy for TNBC. Methods. We identified 148 patients with 151 Stage I-III TNBC treated with neoadjuvant chemotherapy. Residual tumor size was estimated by MMG, US, and/or MRI prior to surgical intervention and compared to the subsequent pathologic residual tumor size. Data were compared using chi-squared test. Results. Of 151 tumors, 44 (29%) did not have imaging performed prior to surgical treatment. Thirty-eight (25%) tumors underwent a pathologic complete response (pCR), while 113 (75%) had residual invasive disease. The imaging modality was accurate to within 1 cm of the final pathologic residual disease in 74 (69%) cases and within 2 cm in 94 (88%) cases. Groups were similar with regards to patient age, race, tumor size and grade, and clinical stage (P > 0.05). Accuracy to within 1 cm was the highest for US (83%) and the lowest for MMG (56%) (P < 0.05). Conclusions. Breast US and MRI were more accurate than MMG in predicting residual tumor size following neoadjuvant chemotherapy in patients with TNBC. None of the imaging modalities were predictive of a pCR.
Authors:
Jordan J Atkins; Catherine M Appleton; Carla S Fisher; Feng Gao; Julie A Margenthaler
Related Documents :
11105709 - The use of clinical ct for baseline bone density assessment.
1407869 - Vertebral metastases and an equivocal bone scan: value of magnetic resonance imaging.
9259099 - Mri gadolinium enhancement of bone marrow: age-related changes in normals and in diffus...
7554659 - Mai osteomyelitis. 18-year scintigraphic follow-up.
6481459 - Should single-phase radionuclide bone imaging be used in suspected osteomyelitis?
8727179 - Magnetic resonance imaging versus bone scan for assessment of vascularization of the hy...
23416829 - Intradural intramedullary spinal cord meningioma in a seven years old female child.
25055279 - Diagnostic utility of mri and mr arthrography for detection of ligamentum teres tears: ...
21157209 - False-positive indium 111 pentetreotide scan for recurrent meningioma due to radiation ...
Publication Detail:
Type:  Journal Article     Date:  2013-02-11
Journal Detail:
Title:  Journal of oncology     Volume:  2013     ISSN:  1687-8450     ISO Abbreviation:  J Oncol     Publication Date:  2013  
Date Detail:
Created Date:  2013-03-11     Completed Date:  2013-03-12     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  101496537     Medline TA:  J Oncol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  964863     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
P30 CA091842/CA/NCI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Enhancement of Cisplatin-Mediated Apoptosis in Ovarian Cancer Cells through Potentiating G2/M Arrest...
Next Document:  Zinc Protoporphyrin Upregulates Heme Oxygenase-1 in PC-3 Cells via the Stress Response Pathway.