| Which feeding option is safer for the HIV exposed infant in sub-Saharan Africa? A critical appraisal of randomized controlled trials. | |
| | |
MedLine Citation:
|
PMID: 21970254 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BACKGROUND: Breast milk is a source of optimal nutrition and protection against serious infectious childhood diseases, but carries with it the risk of transmission of the HIV virus to the infant. Therefore, to breast feed or not, remains a dilemma for the HIV positive woman in sub-Saharan Africa. This manuscript critically examines findings from randomized controlled trials to draw evidence available on infant feeding options for HIV exposed infants in sub-Saharan Africa. METHODOLOGY: Primary literature was search on Pub med with the following MeSH terms-"Breastfeeding"; "HIV"; "Infant Formula"; and "sub-Saharan Africa". Randomized Controlled Trials on infant feeding strategies done in sub-Saharan Africa with clinicaltrial.gov registration numbers, published between 2000 and 2009 were eligible for review. The main outcome assessed was postnatal HIV transmission rates, HIV-free survival and infant mortality. RESULTS: A total of 9 randomized controlled trials were assessed for eligibility and 4 fulfilled the inclusion criteria for review. Evidence drawn from the findings of four out of 9 (4/9) randomized controlled trials done in sub-Saharan Africa settings supports breastfeeding as an optimal and safe option for the HIV exposed infant in most settings of sub-Saharan Africa faced with challenges of poor access to clean portable water and other socioeconomic limitations. The various study settings, main outcome measures and the principal findings and conclusions are summarised in table 1. CONCLUSION: The findings from the various randomized controlled trials in this review support the practice of breastfeeding with antiretroviral therapy to the mother as a safer option for the HIV-exposed infant in sub-SaharanAfrica. |
| | |
Authors:
|
Jonah Musa |
Related Documents
:
|
17474954 - Use of nonsteroidal anti-inflammatory drugs in infants. a survey of members of the asso... 3252754 - Pharmacokinetics of ly163892 in infants and children. 10562624 - Density dependence of forced expiratory flows in healthy infants and toddlers. 20638374 - Making sense of epidemiological studies of young children exposed to thimerosal in vacc... 2696154 - A seroepidemiological study to evaluate the role of passive maternal immunity to malari... 16938754 - Safe reduction in administration of naloxone to newborn infants: an observational study. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria Volume: 20 ISSN: 1115-2613 ISO Abbreviation: Niger J Med Publication Date: 2011 Jan-Mar |
Date Detail:
|
Created Date: 2011-10-05 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100888321 Medline TA: Niger J Med Country: Nigeria |
Other Details:
|
Languages: eng Pagination: 15-9 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynaecology, University of Jos/Jos University Teaching Hospital, Jos, Nigeria. Drmusaj@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pterygium: A review of clinical features and surgical treatment.
Next Document: Gender issues in reproductive health: a review.