Document Detail


Which factors influence age at onset and rate of progression in Huntington's disease?
MedLine Citation:
PMID:  2960786     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fifty-one families of patients affected with Huntington's chorea were interviewed with respect to age at onset, symptoms at onset and course of the disease. The interview further comprised questions pertinent to line of transmission, socio-economic status, housing, previous illnesses and pregnancy and stillbirth. Since the study was set up as a fishing expedition detailed quantitative information was gathered on many life-style factors including eating, drinking and smoking habits. In adult age onset cases earlier age at onset correlated with lower rate of progression. Line of transmission was of no influence on age at onset in cases with onset above 20 years. No statistically significant relationship was found between any factor studied and age at onset, except for the intake of milk. Higher previous milk intake was associated with earlier ages at onset. This finding is critically discussed. No difference was found between the respective ages at onset of conduct disorders and affective disorders. This suggests that they are both associated with the Huntington gene.
Authors:
O J Buruma; W Van der Kamp; E C Barendswaard; R A Roos; D Kromhout; E A Van der Velde
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  80     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-12-22     Completed Date:  1987-12-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  299-306     Citation Subset:  IM    
Affiliation:
Department of Neurology, Academic Hospital Leiden, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Diet
Environment*
Female
Humans
Huntington Disease / epidemiology*,  etiology
Male
Middle Aged
Netherlands
Smoking
Socioeconomic Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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