Document Detail

Which Cholinesterase Inhibitor is the Safest for the Heart in Elderly Patients With Alzheimer's Disease?
MedLine Citation:
PMID:  22573283     Owner:  NLM     Status:  In-Data-Review    
Objective: Cholinesterase inhibitors (ChEIs) are widely used for the treatment of Alzheimer's disease (AD); however, their cholinergic side effects on the cardiovascular system are still unclear. In this study, we aimed to examine the side effects caused by donepezil, rivastigmine, and galantamine on cardiac rhythm and postural blood pressure changes in elderly patients with AD. Methods: Of 204 consecutive elderly patients who were newly diagnosed with AD, 162 were enrolled and underwent comprehensive geriatric assessments. The electrocardiographs (ECGs) and blood pressures were recorded at the baseline and 4 weeks after the dose of 10 mg/d of donepezil, 10 cm(2)/d of rivastigmine, and 24 mg/d of galantamine. Results: There were no changes relative to the baseline in any of the ECG parameters or arterial blood pressure with any of the administered ChEIs. Conclusion: It was demonstrated that none of the 3 ChEIs were associated with increased negative chronotropic, arrhythmogenic, and hypotensive effects for the elderly patients with AD.
Ahmet Turan Isik; Ergun Bozoglu; Adnan Yay; Pinar Soysal; Umit Ateskan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of Alzheimer's disease and other dementias     Volume:  27     ISSN:  1938-2731     ISO Abbreviation:  Am J Alzheimers Dis Other Demen     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101082834     Medline TA:  Am J Alzheimers Dis Other Demen     Country:  United States    
Other Details:
Languages:  eng     Pagination:  171-4     Citation Subset:  IM    
1Department of Geriatric Medicine, Bezmialem Vakif University, Istanbul, Turkey.
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