Document Detail

Whey feeding suppresses the measurement of oxidative stress in experimental burn injury.
MedLine Citation:
PMID:  16554996     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Burns cause thermal injury to local tissue and trigger systemic acute inflammatory processes, which may lead to multiple distant organ dysfunction. We investigated the protective effect of dietary whey supplementation on distant organs in a rat model. METHODS: Forty-eight rats were divided into six groups of eight: groups 1 and 2 were the controls, fed a standard diet and a whey-supplemented diet, respectively; groups 3 and 4 were fed a standard diet and subjected to burn injury; and groups 5 and 6 were fed a whey-supplemented diet and subjected to burn injury. We measured the oxidative stress variables, as well as glutathione in the liver and kidney, and histologically examined skin samples obtained 4 h (groups 3 and 5) and 72 h (groups 4 and 6) after burn injury. RESULTS: Glutathione (GSH) levels remained the same in the liver but were slightly elevated in the kidneys after burn injury in the rats fed a standard diet. Whey supplementation caused a significant increase in hepatic GSH levels 4 h after burn injury. Moreover, there was a significant rebound effect in the liver and kidney GSH levels after 72 h and whey supplementation potentiated this effect. Hepatic and renal lipid peroxide levels were also increased 4 h after burn injury in the rats fed a standard diet. Whey supplementation significantly suppressed the burn-induced increase in hepatic and renal lipid peroxide levels. Histological examination revealed that although whey supplementation resulted in decreased subepidermal inflammation, the indicators of wound healing and collagen deposition were not improved. CONCLUSION: Whey pretreatment suppressed hepatic and renal oxidative stress measurements after experimental burn injury.
Osman Z Oner; Ayliz Velioğlu Oğünç; Asim Cingi; Süheyla Bozkurt Uyar; A Süha Yalçin; A Ozdemir Aktan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgery today     Volume:  36     ISSN:  0941-1291     ISO Abbreviation:  Surg. Today     Publication Date:  2006  
Date Detail:
Created Date:  2006-03-23     Completed Date:  2006-10-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204360     Medline TA:  Surg Today     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  376-81     Citation Subset:  IM    
Department of General Surgery, Marmara University, Tophanelioğlu cad., Altunizede, Istanbul, Turkey.
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MeSH Terms
Burns / complications,  pathology,  physiopathology*
Dairy Products*
Dietary Supplements*
Milk Proteins / pharmacology*
Models, Animal
Nutritional Status*
Oxidative Stress* / drug effects,  physiology
Rats, Wistar
Reg. No./Substance:
0/Milk Proteins; 0/whey protein; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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