Document Detail


Where and how do anthrax toxins exit endosomes to intoxicate host cells?
MedLine Citation:
PMID:  17983750     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of Bacillus anthracis virulence factors in its pathogenesis has been subjected to intense investigation with the aim of finding novel preventive and therapeutic protocols. Toxins that are endocytosed and act in the cytosol of host cells have a central role in B. anthracis infection. Understanding of anthrax toxin cell entry has increased during the past few years and a composite picture is emerging. Nevertheless, unanswered and controversial questions remain, particularly concerning the site and mode of anthrax toxin cell entry, the role of anthrax toxin receptors in the process and the possible involvement of cytosolic chaperones, which might affect entry efficiency. Here, the current model of anthrax toxin cell entry, an alternative model and experimental approaches for clarifying unanswered questions will be discussed.
Authors:
Andrea Puhar; Cesare Montecucco
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-05
Journal Detail:
Title:  Trends in microbiology     Volume:  15     ISSN:  0966-842X     ISO Abbreviation:  Trends Microbiol.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-20     Completed Date:  2008-02-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9310916     Medline TA:  Trends Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  477-82     Citation Subset:  IM    
Affiliation:
Dipartimento di Scienze Biomediche Sperimentali, Università di Padova, viale G. Colombo 3, I-35121 Padua, Italy. andrea.puhar@unipd.it
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MeSH Terms
Descriptor/Qualifier:
Animals
Anthrax / microbiology*
Antigens, Bacterial / metabolism*
Bacillus anthracis / pathogenicity*
Bacterial Toxins / metabolism*
Cytosol / metabolism*
Endocytosis
Endosomes / metabolism*
Humans
Molecular Chaperones / metabolism
Receptors, Peptide / metabolism
Spores, Bacterial / physiology
Chemical
Reg. No./Substance:
0/Antigens, Bacterial; 0/Bacterial Toxins; 0/Molecular Chaperones; 0/Receptors, Peptide; 0/anthrax toxin; 0/anthrax toxin receptors

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