Document Detail


Where does indolylacrylic acid come from?
MedLine Citation:
PMID:  10707769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In addition to the main catabolic routes of tryptophan (Trp), there exist minor and less thoroughly investigated pathways; one of these leads to indolylacrylic acid (IAcrA). IAcrA is a plant growth hormone, whereas its biological role in animals is still obscure, as is the way and site where it is formed in the organism. A two-stage production is likely: Intestinal microorganisms catabolize Trp to indole derivatives which are then absorbed and converted to IAcrA and its glycine conjugate, indolylacryloylglycine (IAcrGly). Our finding of IAcrGly in the urine of proven germ-free piglets points to the possibility that Trp can be converted to IAcrA without the intervention of intestinal microorganisms. Seasonal and age variations, influence of light and connection with photodermatoses have been reported. Besides other pathological conditions the differences in IAcrGly excretion relative to normal controls were especially pronounced in some myopathies, namely in boys with Duchenne muscular dystrophy.
Authors:
E Marklová
Related Documents :
6191759 - Effects of amino acids, glucagon, insulin and acetylcholine on cyclic nucleotide metabo...
19076299 - Molecular physiology of adventitious root formation in petunia hybrida cuttings: involv...
2046209 - Gnrh analogs in reproductive medicine.
21391259 - Effect of d-amino acid oxidase activator (daoa; g72) on brain function during verbal fl...
2881579 - Effects of glucocorticoid and thyroid hormones on regulatory enzymes of fatty acid synt...
3548429 - Effects of d-amino acid substituents on degradation of lhrh analogues by proximal tubule.
404159 - Bile acid metabolism in ileostomy patients.
17123759 - Bioassay-guided isolation of anti-inflammatory and antinociceptive glycoterpenoids from...
8263409 - Absorption and distribution of arachidonate in rats receiving lysophospholipids by oral...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Amino acids     Volume:  17     ISSN:  0939-4451     ISO Abbreviation:  Amino Acids     Publication Date:  1999  
Date Detail:
Created Date:  2000-03-24     Completed Date:  2000-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  401-13     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, Faculty of Medicine & Faculty Hospital, Charles University, Hradec Králové, Czech Republic. marklova@lfhk.cuni.cz
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aging / metabolism
Burns / metabolism
Diet
Glycine / analogs & derivatives,  metabolism,  urine
Humans
Indoles / metabolism*
Muscular Dystrophies / metabolism
Skin Diseases / metabolism
Tryptophan / metabolism*
Urinary Bladder Neoplasms / metabolism
Chemical
Reg. No./Substance:
0/Indoles; 1204-06-4/indoleacrylic acid; 3475-68-1/indolylacryloylglycine; 56-40-6/Glycine; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Inhibitory effect of arginine-derivatives from ginseng extract and basic amino acids on protein-argi...
Next Document:  Lymphoma classification--from controversy to consensus: the R.E.A.L. and WHO Classification of lymph...