| Where does indolylacrylic acid come from? | |
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MedLine Citation:
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PMID: 10707769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In addition to the main catabolic routes of tryptophan (Trp), there exist minor and less thoroughly investigated pathways; one of these leads to indolylacrylic acid (IAcrA). IAcrA is a plant growth hormone, whereas its biological role in animals is still obscure, as is the way and site where it is formed in the organism. A two-stage production is likely: Intestinal microorganisms catabolize Trp to indole derivatives which are then absorbed and converted to IAcrA and its glycine conjugate, indolylacryloylglycine (IAcrGly). Our finding of IAcrGly in the urine of proven germ-free piglets points to the possibility that Trp can be converted to IAcrA without the intervention of intestinal microorganisms. Seasonal and age variations, influence of light and connection with photodermatoses have been reported. Besides other pathological conditions the differences in IAcrGly excretion relative to normal controls were especially pronounced in some myopathies, namely in boys with Duchenne muscular dystrophy. |
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Authors:
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E Marklová |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Amino acids Volume: 17 ISSN: 0939-4451 ISO Abbreviation: Amino Acids Publication Date: 1999 |
Date Detail:
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Created Date: 2000-03-24 Completed Date: 2000-03-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9200312 Medline TA: Amino Acids Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 401-13 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, Faculty of Medicine & Faculty Hospital, Charles University, Hradec Králové, Czech Republic. marklova@lfhk.cuni.cz |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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metabolism Burns / metabolism Diet Glycine / analogs & derivatives, metabolism, urine Humans Indoles / metabolism* Muscular Dystrophies / metabolism Skin Diseases / metabolism Tryptophan / metabolism* Urinary Bladder Neoplasms / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Indoles; 1204-06-4/indoleacrylic acid; 3475-68-1/indolylacryloylglycine; 56-40-6/Glycine; 73-22-3/Tryptophan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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