Document Detail

Where does indolylacrylic acid come from?
MedLine Citation:
PMID:  10707769     Owner:  NLM     Status:  MEDLINE    
In addition to the main catabolic routes of tryptophan (Trp), there exist minor and less thoroughly investigated pathways; one of these leads to indolylacrylic acid (IAcrA). IAcrA is a plant growth hormone, whereas its biological role in animals is still obscure, as is the way and site where it is formed in the organism. A two-stage production is likely: Intestinal microorganisms catabolize Trp to indole derivatives which are then absorbed and converted to IAcrA and its glycine conjugate, indolylacryloylglycine (IAcrGly). Our finding of IAcrGly in the urine of proven germ-free piglets points to the possibility that Trp can be converted to IAcrA without the intervention of intestinal microorganisms. Seasonal and age variations, influence of light and connection with photodermatoses have been reported. Besides other pathological conditions the differences in IAcrGly excretion relative to normal controls were especially pronounced in some myopathies, namely in boys with Duchenne muscular dystrophy.
E Marklová
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Amino acids     Volume:  17     ISSN:  0939-4451     ISO Abbreviation:  Amino Acids     Publication Date:  1999  
Date Detail:
Created Date:  2000-03-24     Completed Date:  2000-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  401-13     Citation Subset:  IM    
Department of Paediatrics, Faculty of Medicine & Faculty Hospital, Charles University, Hradec Králové, Czech Republic.
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MeSH Terms
Aging / metabolism
Burns / metabolism
Glycine / analogs & derivatives,  metabolism,  urine
Indoles / metabolism*
Muscular Dystrophies / metabolism
Skin Diseases / metabolism
Tryptophan / metabolism*
Urinary Bladder Neoplasms / metabolism
Reg. No./Substance:
0/Indoles; 1204-06-4/indoleacrylic acid; 3475-68-1/indolylacryloylglycine; 56-40-6/Glycine; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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