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Where the boys aren't: dioxin and the sex ratio.
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MedLine Citation:
PMID:  11781158     Owner:  NLM     Status:  MEDLINE    
The question of how exposure to dioxins might affect only males and why it affects preferentially male embryos in the Seveso data presented by Mocarelli et al. remains intriguing. This enigma can be explained by the ovopathy concept, which addresses the determination of both the sex and the condition of the progeny. Antiandrogenic properties of dioxin alter the sperm-transit time and mating behavior, which provoke delay of fertilization of the oocyte (postovulatory overripeness of the oocyte). Antiestrogenic properties of dioxin during mid-cycle compromise both mucus liquefaction and maturation of the oocyte (preovulatory overripeness ovopathy). A positive dose-response of male-biased pathologic conceptuses is often followed by a negative one due to "vanishing male conceptuses." This dose-response fallacy is present in animal experiments and explains many otherwise unexplained phenomena related to dioxin contamination and other high-risk conceptions.
Piet Hein Jongbloet; Nel Roeleveld; Hans M M Groenewoud
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Environmental health perspectives     Volume:  110     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-01-08     Completed Date:  2002-02-12     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-3     Citation Subset:  IM    
Department of Epidemiology and Biostatistics, University Medical Centre, Nijmegen, The Netherlands.
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MeSH Terms
Dioxins / adverse effects*
Dose-Response Relationship, Drug
Embryonic and Fetal Development / drug effects*
Environmental Exposure*
Environmental Pollutants / adverse effects*
Fertilization / drug effects
Ovulation / drug effects
Sex Ratio*
Reg. No./Substance:
0/Dioxins; 0/Environmental Pollutants
Comment In:
Environ Health Perspect. 2002 Sep;110(9):A502; discussion A502   [PMID:  12204835 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 1 Year: 2002
Volume: 110 Issue: 1
First Page: 1 Last Page: 2
ID: 1240686
Publisher Id: ehp0110-000001
PubMed Id: 11781158

Dioxin and the Sex Ratio
PH Jongbloet

Article Categories:
  • Where the Boys Aren't

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