| Where the O2 goes to: preservation of human fetal oxygen delivery and consumption at high altitude. | |
| | |
MedLine Citation:
|
PMID: 19074967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Fetal growth is decreased at high altitude (> 2700 m). We hypothesized that variation in fetal O(2) delivery might account for both the altitude effect and the relative preservation of fetal growth in multigenerational natives to high altitude. Participants were 168 women of European or Andean ancestry living at 3600 m or 400 m. Ancestry was genetically confirmed. Umbilical vein blood flow was measured using ultrasound and Doppler. Cord blood samples permitted calculation of fetal O(2) delivery and consumption. Andean fetuses had greater blood flow and oxygen delivery than Europeans and weighed more at birth, regardless of altitude (+208 g, P < 0.0001). Fetal blood flow was decreased at 3600 m (P < 0.0001); the decrement was similar in both ancestry groups. Altitude-associated decrease in birth weight was greater in Europeans (-417 g) than Andeans (-228 g, P < 0.005). Birth weight at 3600 m was > 200 g lower for Europeans at any given level of blood flow or O(2) delivery. Fetal haemoglobin concentration was increased, decreased, and the fetal / curve was left-shifted at 3600 m. Fetuses receiving less O(2) extracted more (r(2) = 0.35, P < 0.0001). These adaptations resulted in similar fetal O(2) delivery and consumption across all four groups. Increased umbilical venous O(2) delivery correlated with increased fetal O(2) consumption per kg weight (r(2) = 0.50, P < 0.0001). Blood flow (r(2) = 0.16, P < 0.001) and O(2) delivery (r(2) = 0.17, P < 0.001) correlated with birth weight at 3600 m, but not at 400 m (r(2) = 0.04, and 0.03, respectively). We concluded that the most pronounced difference at high altitude is reduced fetal blood flow, but fetal haematological adaptation and fetal capacity to increase O(2) extraction indicates that deficit in fetal oxygen delivery is unlikely to be causally associated with the altitude- and ancestry-related differences in fetal growth. |
| | |
Authors:
|
Lucrecia Postigo; Gladys Heredia; Nicholas P Illsley; Tatiana Torricos; Caitlin Dolan; Lourdes Echalar; Wilma Tellez; Ivan Maldonado; Michael Brimacombe; Elfride Balanza; Enrique Vargas; Stacy Zamudio |
Related Documents
:
|
11254227 - Cardiovascular responses to arginine vasopressin blockade during acute hypoxemia in the... 10560887 - Obstetric evaluation of fetal acid-base balance. 12797127 - Maternal hyperoxygenation in the treatment of mild intrauterine growth retardation: a p... 8242257 - The effects of a converting enzyme inhibitor (captopril) and angiotensin ii on fetal re... 8208117 - Three-dimensional time-of-flight mr angiography using selective inversion recovery rage... 21445797 - Modeling o(2)-dependent effects of nitrite reductase activity in blood and tissue on co... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2008-12-15 |
Journal Detail:
|
Title: The Journal of physiology Volume: 587 ISSN: 1469-7793 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2009 Feb |
Date Detail:
|
Created Date: 2009-02-02 Completed Date: 2009-05-06 Revised Date: 2010-09-22 |
Medline Journal Info:
|
Nlm Unique ID: 0266262 Medline TA: J Physiol Country: England |
Other Details:
|
Languages: eng Pagination: 693-708 Citation Subset: IM |
Affiliation:
|
Hospital Materno-Infantil, Universidad de San Andreas Mayor, La Paz, Bolivia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acclimatization* Altitude* Blood Flow Velocity Blood Gas Analysis European Continental Ancestry Group Female Fetal Blood* Fetal Development / physiology* Fetal Hemoglobin / analysis Humans Indians, South American Infant, Newborn Oxygen* / blood Pregnancy Regional Blood Flow / physiology Umbilical Arteries / anatomy & histology, physiology Umbilical Veins / anatomy & histology, physiology Vascular Resistance |
| Grant Support | |
ID/Acronym/Agency:
|
HD 42737/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
7782-44-7/Oxygen; 9034-63-3/Fetal Hemoglobin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Taurine uptake across the human intestinal brush-border membrane is via two transporters: H(+)-coupl...
Next Document: Rapid and local autoregulation of cerebrovascular blood flow: a deep-brain imaging study in the mous...