Document Detail

Whence directionality: guidance mechanisms in solitary and collective cell migration.
MedLine Citation:
PMID:  21238921     Owner:  NLM     Status:  In-Process    
As individual cells or groups of cells move through the complex environment of the body, their migration is affected by multiple external cues. Some cues are diffusible signaling molecules, and some are solid biophysical features. How do cells respond appropriately? This perspective discusses the relationship between guidance input and the cellular output, considering effects from classical chemotaxis to contact-dependent guidance. The influences of membrane trafficking and of imposed constraints on directional movement are also considered. New insights regarding guidance and dynamic cell polarity have emerged from examining new cell migration models and from re-examining well known ones with new approaches and new tools.
Pernille Rørth
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental cell     Volume:  20     ISSN:  1878-1551     ISO Abbreviation:  Dev. Cell     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9-18     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Institute of Molecular and Cell Biology, Singapore 138673, Singapore.
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