Document Detail


When is weaker better? Design of an ADP sensor with weak ADP affinity, but still selective against ATP.
MedLine Citation:
PMID:  20394442     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A simple ADP biosensor would be of broad usefulness in monitoring the large number of metabolic processes that produce ADP. Several new systems have been recently described including one in the current issue of ACS Chemical Biology that provides a simple readout of the ADP concentration without significant interference by ATP.
Authors:
David D Hackney
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  ACS chemical biology     Volume:  5     ISSN:  1554-8937     ISO Abbreviation:  ACS Chem. Biol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-16     Completed Date:  2010-06-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101282906     Medline TA:  ACS Chem Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  353-4     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA. ddh@andrew.cmu.edu
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MeSH Terms
Descriptor/Qualifier:
Actins / chemistry,  metabolism
Adenosine Diphosphate / analysis*,  metabolism
Adenosine Triphosphate / analysis,  metabolism
Biosensing Techniques / methods*
Escherichia coli / chemistry,  metabolism
Escherichia coli Proteins / chemistry,  metabolism
Fluorescence
Models, Molecular
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Actins; 0/Escherichia coli Proteins; 0/ParM protein, E coli; 56-65-5/Adenosine Triphosphate; 58-64-0/Adenosine Diphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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